… , natural products … of natural products have greatly advanced, but tracking the
bioactivity—including cytotoxicity—remains a key issue hampering a larger exploitation of natural …

… intrinsic properties of the substrate rather than by characteristics of … natural products, including
lanthipeptides, sactipeptides, and polyketides. Understanding the mechanism of substrate-…

… plant cell cultures, although this could be a most useful substrate … is probably the best carbon
substrate if biomass yield is the … natural product synthesis may be influenced by the nature …

… of the substrate specificity of the … natural substrate of the enzyme. The very low yield of
eriodictyol obtained with caffeoyl-CoA suggests that this CoA thiol ester is not a natural substrate …

… We used a natural product-inspired compound library to identify non-substrate-based … , to
identify new non-substrate-based XT-I inhibitors from natural compounds that could potentially …

… of ILK kinase activity upon cell attachment to ECM substrates and stimulation with growth
factors; and … It covers in detail the complicated nature of integrin-activated signaling pathways …

… of associated and independent factors which include substrate and/or product inhibition/toxicity,
cell damage due to process conditions and natural cell death. Moreover, some factors …

… Our results concur with the diversity-based model of natural product biosynthesis which
proposes that organisms use a small number of pathways for generating multiple secondary …

… Natural products, for many years the touchstones of structural and synthetic organic … the
few cell-free systems that have been developed to study the biosynthesis of natural products, the …

… The main use of microbial cell cultures for biotransformation of natural products which mimic
mammalian biotransformation (metabolism) will provide required amounts of metabolites for …