Natural products: Key prototypes to drug discovery against neglected diseases caused by trypanosomatids

MT Varela, JPS Fernandes - Current medicinal chemistry, 2020 - ingentaconnect.com
drugs to Chagas’ disease and leishmaniasis still old synthetic toxic molecules? Would natural
products … we made a discussion on natural products as molecular prototypes for designing …

Natural products to anti-trypanosomal drugs: an overview of new drug prototypes for American Trypanosomiasis

AG Tempone, P Sartorelli, C Mady… - … Agents in Medicinal …, 2007 - ingentaconnect.com
… Considering anti-trypanosomal substances as potential chemotherapeutic agents for treatment
of Chagas’ disease, in this review, we have selected only the natural products displaying …

Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes

T Silva, J Reis, J Teixeira, F Borges - Ageing research reviews, 2014 - Elsevier
Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly
destroys brain cells. This disease progressively compromises both memory and cognition, …

Diterpenes from European Euphorbia Species Serving as Prototypes for NaturalProduct‐Based Drug Discovery

A Vasas, D Rédei, D Csupor, J Molnár… - European journal of …, 2012 - Wiley Online Library
… in the context of natural product drug discovery programs … drug development, some of which
are currently involved in preclinical or clinical studies, but the importance of natural products

Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey

S Hanessian - ChemMedChem: Chemistry Enabling Drug …, 2006 - Wiley Online Library
… synthesis of natural productsnatural products in conjunction with X-ray crystallography,
molecular modeling, and NMR spectroscopy for the design and synthesis of new drug prototypes

Counting on natural products for drug design

T Rodrigues, D Reker, P Schneider, G Schneider - Nature chemistry, 2016 - nature.com
… Here we discuss natural-product-inspired drug … mimic nature's chemistry. We highlight the
potential of innovative computational tools in processing structurally complex natural products

Natural products as a resource for new drugs

AM Clark - Pharmaceutical research, 1996 - Springer
… A final example of the importance of natural product drug … In these cases, the natural
product serves as a prototype lead … of the original prototype natural product are required for …

Natural products in drug discovery

AL Harvey - Drug discovery today, 2008 - Elsevier
… presented on sources of new drugs from 1981 to 2007 2, 3 indicate that almost half of … drugs
approved since 1994 are based on natural products. Thirteen natural-product-related drugs

[PDF][PDF] Recent natural products based drug development: a pharmaceutical industry perspective

YZ Shu - Journal of natural products, 1998 - chem.uwec.edu
… thus, the role that natural products have played historically in … of important natural
product-based drug developments in the … of natural products research to overall drug discovery …

The role of natural products in modern drug discovery.

JB Calixto - Anais da Academia Brasileira de Ciências, 2019 - SciELO Brasil
… and phytomedicines); ii) a source of raw material for development of complex, semi-synthetic
drugs; iii) prototypes for design of lead molecules; iv) as taxonomic markers for discovery of …