Natural products: Key prototypes to drug discovery against neglected diseases caused by trypanosomatids
MT Varela, JPS Fernandes - Current medicinal chemistry, 2020 - ingentaconnect.com
… drugs to Chagas’ disease and leishmaniasis still old synthetic toxic molecules? Would natural
products … we made a discussion on natural products as molecular prototypes for designing …
products … we made a discussion on natural products as molecular prototypes for designing …
Natural products to anti-trypanosomal drugs: an overview of new drug prototypes for American Trypanosomiasis
AG Tempone, P Sartorelli, C Mady… - … Agents in Medicinal …, 2007 - ingentaconnect.com
… Considering anti-trypanosomal substances as potential chemotherapeutic agents for treatment
of Chagas’ disease, in this review, we have selected only the natural products displaying …
of Chagas’ disease, in this review, we have selected only the natural products displaying …
Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes
Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly
destroys brain cells. This disease progressively compromises both memory and cognition, …
destroys brain cells. This disease progressively compromises both memory and cognition, …
Diterpenes from European Euphorbia Species Serving as Prototypes for Natural‐Product‐Based Drug Discovery
… in the context of natural product drug discovery programs … drug development, some of which
are currently involved in preclinical or clinical studies, but the importance of natural products …
are currently involved in preclinical or clinical studies, but the importance of natural products …
Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey
S Hanessian - ChemMedChem: Chemistry Enabling Drug …, 2006 - Wiley Online Library
… synthesis of natural products … natural products in conjunction with X-ray crystallography,
molecular modeling, and NMR spectroscopy for the design and synthesis of new drug prototypes…
molecular modeling, and NMR spectroscopy for the design and synthesis of new drug prototypes…
Counting on natural products for drug design
… Here we discuss natural-product-inspired drug … mimic nature's chemistry. We highlight the
potential of innovative computational tools in processing structurally complex natural products …
potential of innovative computational tools in processing structurally complex natural products …
Natural products as a resource for new drugs
AM Clark - Pharmaceutical research, 1996 - Springer
… A final example of the importance of natural product drug … In these cases, the natural
product serves as a prototype lead … of the original prototype natural product are required for …
product serves as a prototype lead … of the original prototype natural product are required for …
Natural products in drug discovery
AL Harvey - Drug discovery today, 2008 - Elsevier
… presented on sources of new drugs from 1981 to 2007 2, 3 indicate that almost half of … drugs
approved since 1994 are based on natural products. Thirteen natural-product-related drugs …
approved since 1994 are based on natural products. Thirteen natural-product-related drugs …
[PDF][PDF] Recent natural products based drug development: a pharmaceutical industry perspective
YZ Shu - Journal of natural products, 1998 - chem.uwec.edu
… thus, the role that natural products have played historically in … of important natural
product-based drug developments in the … of natural products research to overall drug discovery …
product-based drug developments in the … of natural products research to overall drug discovery …
The role of natural products in modern drug discovery.
JB Calixto - Anais da Academia Brasileira de Ciências, 2019 - SciELO Brasil
… and phytomedicines); ii) a source of raw material for development of complex, semi-synthetic
drugs; iii) prototypes for design of lead molecules; iv) as taxonomic markers for discovery of …
drugs; iii) prototypes for design of lead molecules; iv) as taxonomic markers for discovery of …
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