Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019

DJ Newman, GM Cragg - Journal of natural products, 2020 - ACS Publications
… on sources of novel antibiotics from Nature due to the absolute … that a significant number of
natural product drugs/leads are … natural product research should be expanded significantly. …

Natural products as potential lead compounds to develop new antiviral drugs over the past decade

JH Zhao, YW Wang, J Yang, ZJ Tong, JZ Wu… - European Journal of …, 2023 - Elsevier
… microorganisms in nature with rich structural skeletons, and they are natural treasure house
… the natural products with antiviral activity that had been reported for the first time in the past

Natural product discovery: past, present, and future

L Katz, RH Baltz - Journal of Industrial Microbiology and …, 2016 - academic.oup.com
… Over the past seven decades, natural product … next two decades. Overall efforts in NP
discovery have decelerated with the waning interest from the pharmaceutical industry over the past

Natural products for cancer therapy: a review of their mechanism of actions and toxicity in the past decade

YO Ali Abdalla, B Subramaniam… - Journal of Tropical …, 2022 - Wiley Online Library
… Despite the positive attributes of natural products, there are many questions pertaining to …
on natural products that are recently been investigated extensively in the past decade for their …

Drug discovery and natural products: end of an era or an endless frontier?

JWH Li, JC Vederas - Science, 2009 - science.org
… However, many pharmaceutical firms have eliminated their natural product research in the
past decade. Although more than 100 natural product–based drugs are in clinical studies, this …

[HTML][HTML] Trends in the discovery of new marine natural products from invertebrates over the last two decades–where and what are we bioprospecting?

MC Leal, J Puga, J Serodio, NCM Gomes, R Calado - PLoS One, 2012 - journals.plos.org
… discovery over the past two decades, taking … decades?. Beyond the importance of the
outcome of the present work for several research fields associated with marine natural products (…

[PDF][PDF] Recent natural products based drug development: a pharmaceutical industry perspective

YZ Shu - Journal of natural products, 1998 - chem.uwec.edu
… mg bid43,44 In the antidiabetes area, the past decade has witnessed the market introduction
of several R-glucosidase inhibitors derived from natural products. Acarbose, a complex of …

Natural products as sources of new drugs from 1981 to 2014

DJ Newman, GM Cragg - Journal of natural products, 2016 - ACS Publications
… (102) We have continued our attempts to capture vaccine data for the past few years, but …
and 30% in the other years of the second decade of the 21st century. The mean and standard …

[HTML][HTML] A historical overview of natural products in drug discovery

DA Dias, S Urban, U Roessner - Metabolites, 2012 - mdpi.com
… In the past two decades “classical natural product chemistry” has largely been replaced by
molecular target based drug discovery, utilizing large combinatorial libraries to obtain efficient …

[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review

AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
… In the past decades, pharmaceutical industry focused mainly … interest in drug discovery
from natural sources, despite of its … to plant-derived natural product drug discovery. Associated …