… Chagas disease, caused by Trypanosoma cruzi… natural products, this article reviews 21
years of literature reports on the semisynthesis and total synthesis of new compounds targeting T…

… cruzi have led to the … , natural products, and their derivatives, against a number of
targets. Here, I mainly review recent studies on the antichagasic activities of natural products. …

… natural products of different structural types were tested in vitro against infective blood
trypomastigotes of Trypanosoma cruzi. … This paper reports the results of screening natural products …

… diseases, American trypanosomiasis (Chagas' disease), due to the kinetoplastid protozoon
Tiypanosoma cruzi, is particularly relevant to Latin America. The natural products literature …

… Natural products are the source for structural chemical backbone that could be used to inspire
synthesis of new active molecules. Natural products … lactone class of natural substances …

… cruzi. We have studied the in vitro effects of natural products, obtained from … of the
autochthonous flora of the North of Chile, on trypomastigotes of Trypanosoma cruzi. …

… /mL) in the usual preliminary epimastigote assays (Cuéllar et al., 2003), for practical reasons
we will limit our discussion to natural products active at concentrations of 100 μg/mL or less. …

… of TR from the pathogen Trypanosoma cruzi complexed with the substrate trypanothione
and … have identified a class of cyclic-polyamine natural products that are novel TR inhibitors. …

… Her research interests are antiviral and antiprotozoal activities of natural products. … His
main interests are nanotechnology and antimicrobial activity of natural products, focusing on …

… To identify new compounds active against Trypanosoma cruzi, we designed … natural
products as potential starting points in the development of new molecules that are active against T…