Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes

W Zhao, X Sher - PLoS computational biology, 2018 - journals.plos.org
… ligandome, the reliability of new predictors on these epitopes has yet … MHC-binding predictors
by using newly available, untested data of both synthetic and naturally processed epitopes

Deciphering the MHC-associated peptidome: a review of naturally processed ligand data

K Vaughan, X Xu, E Caron, B Peters… - Expert Review of …, 2017 - Taylor & Francis
… Areas covered: For this, we first analyzed naturally processed peptide (NP) … peptides were
also reported to be T cell epitopes. Thus, the NP data identify only a small subset of epitopes

MHC-NP: predicting peptides naturally processed by the MHC

S Giguère, A Drouin, A Lacoste, M Marchand… - Journal of …, 2013 - Elsevier
… We present MHC-NP, a tool for predicting peptides naturally processed by the MHC pathway…
Our tool is freely available online and hosted by the Immune Epitope Database at http://tools.…

Post-translational modifications of naturally processed MHC-binding epitopes

VH Engelhard, M Altrich-Vanlith, M Ostankovitch… - Current opinion in …, 2006 - Elsevier
… identified in naturally processed MHC-associated peptides, the relationship of PTMs to antigen
… involving disulfide bond formation within naturally processed MHC associated peptides. …

… processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC …

AJ Godkin, KJ Smith, A Willis… - The Journal of …, 2001 - journals.aai.org
MHC class II ligands. There is evidence that addition of C-terminal basic PFRs to known
peptide epitopes is able to enhance both processingepitope identification and vaccine design. …

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2. 1 with high affinity and in different conformations.

YE Chen, J Sidney, S Southwood, AL Cox… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
epitope HIVenv,,,-,,, (26), and the HLA-A1 restricted peptide epitope Mage-1 … In the current
study, the relative affinities of naturally processed peptides for the class I MHC molecule HLA-…

MHC Class I-Restricted Antigen Processing—Lessons from Natural Ligands

HG Rammensee, O Rötzschke, K Falk - Naturally Processed Peptides, 1993 - karger.com
MHC Class I-Restricted Antigen Processing 115 of naturally processed T cell epitopes is to
compare them with synthetic peptides, which is possible if the protein of origin is known. For …

Structure of peptides associated with class I and class II MHC molecules

VH Engelhard - Annual review of immunology, 1994 - annualreviews.org
… of the complexity of naturally processed peptides associated with MHC molecules. Greater
… An important extension of this work is the identification of MHC-restricted peptide epitopes

Footprints of antigen processing boost MHC class II natural ligand predictions

C Barra, B Alvarez, S Paul, A Sette, B Peters… - Genome medicine, 2018 - Springer
… of peptide to MHC-II binding trained with naturally … a naturally processed ligand, we can
assume that the sequence of the validated epitope and the original (but unknown to us) naturally

Peptide HER2 (776–788) represents a naturally processed broad MHC class II-restricted T cell epitope

R Sotiriadou, SA Perez, AD Gritzapis… - British Journal of …, 2001 - nature.com
… 788) as a helper epitope and the identification of its potential promiscuity (broad MHC restriction),
so as … We report here that HER2(776–788) is a helper peptide naturally processed and …