A Soluble Guanylate Cyclase Mediates Negative Signaling by Ammonium on Expression of Nitrate Reductase in Chlamydomonas

A de Montaigu, E Sanz-Luque, A Galvan… - The Plant …, 2010 - academic.oup.com
signals (ie, nitrate) and negative signals (ie, ammonium and ammonium derivatives), which
result in appropriate use of the nitrogen source. In this work, we analyzed negative signaling

Structure and regulation of soluble guanylate cyclase

ER Derbyshire, MA Marletta - Annual review of biochemistry, 2012 - annualreviews.org
… domain and appears to function as a dominant-negative protein (39). Despite the similar …
(sGC) is the most thoroughly characterized receptor for the signaling molecule nitric oxide (…

Negatively calcium-modulated membrane guanylate cyclase signaling system in the rat olfactory bulb

T Duda, V Venkataraman, A Krishnan, RG Nagele… - Biochemistry, 2001 - ACS Publications
… membrane guanylate cyclase (mGC) … , guanylate cyclase activating protein type 1 (GCAP1),
in the mitral cells. Thus, a new facet of the Ca 2+ -modulated GCAP1−ROS-GC1 signaling

Comparison of moonlighting guanylate cyclases: roles in signal direction?

L Freihat, V Muleya, DT Manallack… - Biochemical Society …, 2014 - portlandpress.com
… catalysed by members of the guanylate cyclase (GC) family. … involved in responses to
changes in environmental signals [7,8]. … where it acts as a negative regulator of the inflammatory …

The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease

Ø Brenna, T Bruland, MW Furnes… - Scandinavian journal …, 2015 - Taylor & Francis
Objective. Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in
gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti-…

The guanylate cyclase C—cGMP signaling axis opposes intestinal epithelial injury and neoplasia

JA Rappaport, SA Waldman - Frontiers in oncology, 2018 - frontiersin.org
… a function of synthesis by guanylate cyclases and degradation by phosphodiesterases. …
guanylate cyclase signaling (12, 14). Here, we will focus on the key elements of cGMP signaling

Biochemistry of soluble guanylate cyclase

ER Derbyshire, MA Marletta - cGMP: Generators, Effectors and Therapeutic …, 2009 - Springer
… of homeostasis, and dysfunction in the NO signaling pathway has been linked to several …
to a region within adenylyl cyclases and functions as a dominant negative protein. J Biol Chem …

[HTML][HTML] Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction

EW Godfrey, M Longacher, H Neiswender… - Developmental …, 2007 - Elsevier
… Overexpression of guanylate cyclase (GC) increases AChR aggregation in embryonic
muscles, but a dominant negative GC inhibits endogenous aggregation at NMJs. Embryos were …

Membrane guanylate cyclase is a beautiful signal transduction machine: overview

RK Sharma - Molecular and cellular biochemistry, 2010 - Springer
… (4) The adenylate cyclase responded to the hormonal signals in broken cell preparations
[11… To indicate the intensity and impact of these findings on the negative development of this …

Structural perspectives on the mechanism of soluble guanylate cyclase activation

EC Wittenborn, MA Marletta - International journal of molecular sciences, 2021 - mdpi.com
… H-NOXs are found as standalone proteins that interact with cognate signaling partners,
usually a histidine kinase or a diguanylate cyclase [40,41]. In contrast, obligate anaerobes …