… As effective as antigenic variation may be in evading the consequences of adaptive
immune responses, we further propose that N. gonorrhoeae avoids the generation of specific …

… N. gonorrhoeae is an obligate human pathogen with the ability to evade and modulate
both the innate and adaptive immune systems to benefit its replication and survival. The host-…

… as a pathogen, we propose that it also suppresses specific adaptive immune responses,
including antibody development, that might be capable of eliminating it. Our findings reported …

… In vitro and mouse models have shown that N. gonorrhoeae impairs induction of adaptive
immunity by multiple mechanisms. These include apoptosis of antigen-presenting cells [13], …

… Collectively these findings suggest that N. gonorrhoeae possesses mechanisms to
interfere with the development of host adaptive immune responses that might be capable of …

… gonorrhoeae has previously been shown to engage immunosuppressive signaling … We
have now found that N. gonorrhoeae also suppresses adaptive immune responses through …

… is critically involved in the suppression of adaptive immunity by N. gonorrhoeae, and systemic
treatment with anti–TGF-β or/and anti–IL-10 antibodies reverses the natural capacity of N. …

… The intimate relationship between humans and Neisseria gonorrhoeae infections span
centuries, which is evidenced in … The adaptive immune response in cytotoxic T cell populations to …

… gonorrhoeae utilizes antigenic variation to change the sequence of expressed proteins,
allowing the bacteria to evade the adaptive immune response and/or to alter protein function. …

… proactively elicits Th17-driven innate responses that it can resist and concomitantly suppresses
Th1/Th2-driven specific adaptive immunity that would protect the host. Blockade of TGF-…