… We hypothesize that IL-17-driven innate responses are inadequate to eliminate gonococcal
infection in humans and that potentially protective adaptive immune responses are …

… We examined the ability of NOD1 and NOD2 to recognize Neisseria gonorrhoeae, and
determined the role of NOD-dependent signaling in regulating the immune response to …

… components have the potential to elicit an innate response in mammalian cells, we first tested
a … by a mechanism other than a well-described innate immune agonist/receptor interaction. …

… innate immune cells that sample the surrounding milieu. As a host-adapted organism,
Neisseria gonorrhoeae … activation of innate immune responses at the sites of colonization, as N. …

… , the modulation of the host immune response to evade both innate and adaptive defenses,
and … activities of innate immune cells. Collectively, these pathways act in concert to enable N. …

… sexually transmitted infection termed gonorrhea. The gonococcus … However, upon infection
the host uses a defensive response by … can subvert this defensive response, we examined …

… Information on the innate response to Neisseria gonorrhoeae in women is limited to studies
… 17β-Estradiol-treated BALB/c mice can be experimentally infected with N. gonorrhoeae, and …

… Considering that macrophages are critical cells in the innate immune response to N.
gonorrhoeae, and macrophage-driven innate immune response can be subverted by N. …

… Neisseria gonorrhoeae, the cause of the sexually transmitted infection gonorrhea, elicits low
levels … infection does not alter the Ig response upon subsequent exposure, suggesting that …

The intimate relationship between humans and Neisseria gonorrhoeae infections span
centuries, which is evidenced in case reports from studies dating back to the late 1700s and …