Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

RC Pearson, MM Esiri, RW Hiorns… - Proceedings of the …, 1985 - National Acad Sciences
… areas of the neocortex in brains affected by various degrees of severity of Alzheimer disease.
The … cal involvement in different areas of the neocortex and the laminar distribution and the …

The synaptic organization of the neocortex in Alzheimer's disease

E Masliah, A Miller, RD Terry - Medical hypotheses, 1993 - Elsevier
… -Alzheimer’s disease (… neocortex is derived from loss of cortico-cortical associational input
into the modules. This hypothesis also predicts that neuritic plaque formation in the neocortical

β-Secretase protein and activity are increased in the neocortex in Alzheimer disease

H Fukumoto, BS Cheung, BT Hyman… - Archives of …, 2002 - jamanetwork.com
Context Amyloid plaques, a major pathological feature of Alzheimer disease (AD), are composed
of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-β protein (…

[HTML][HTML] Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study

DA Snowdon, CL Tully, CD Smith, KP Riley… - The American journal of …, 2000 - Elsevier
… of atrophy of the neocortex was −0.40 (P = 0.03). Among a subset of 15 participants with
significant numbers of Alzheimer disease lesions in the neocortex, the correlation between …

Selective disruption of the cerebral neocortex in Alzheimer's disease

…, B Fischl, Alzheimer's Disease Neuroimaging Initiative - PloS one, 2010 - journals.plos.org
… , a surrogate for neocortical NFTs, we examined the relationship between the presence of
Alzheimer's pathology, gray matter thickness of select neocortical regions, and hippocampal …

Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease

MG Tan, WT Chua, MM Esiri, AD Smith… - Journal of …, 2010 - Wiley Online Library
Alzheimer's disease (AD) is characterized by a complex neurodegenerative process affecting
multiple genes and proteins in the neocortex… transcriptome in neocortex is characterized by …

Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus

SW Scheff, DA Price - Journal of Alzheimer's Disease, 2006 - content.iospress.com
… regions of the neocortex may be involved early in the disease process. There was also the
possibility that some type of plasticity may be dysfunctional in the neocortex despite the fact …

Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease

K Chandrasekaran, K Hatanpää, SI Rapoport… - Molecular brain …, 1997 - Elsevier
… cytochrome oxidase (COX) subunits I and III in Alzheimer disease (AD) brains. The decreases
were observed in an association neocortical region (midtemporal cortex) affected in AD, …

BC200 RNA in normal human neocortex, non-Alzheimer dementia (NAD), and senile dementia of the Alzheimer type (AD)

WJ Lukiw, P Handley, L Wong… - Neurochemical …, 1992 - Springer
… in Alzheimer affected neocortex suggests a cause-andeffect relationship. As an index of the
transcriptional competence of neocortical … reduction in Alzheimer's disease. Mol. Brain Res. …

Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease

LM Bierer, PR Hof, DP Purohit, L Carlin… - Archives of …, 1995 - jamanetwork.com
neocortical neuronal degeneration, as indicated by NFT formation, is a critical determinant of
the clinical progression of Alzheimer's diseaseneocortical regions within the temporal lobe. …