… After performing a feasibility study with five neonates, we conducted this randomized, … -ischemic
neonates to determine incidence of adverse neurologic outcomes in neonates who meet …

… Core outcome sets (COSs), a minimum set of outcomes to be measured and reported in all
… identify outcomes reported (primary, secondary, adverse events and other reported outcomes…

… therapy for babies with moderate or severe neonatal encephalopathy (NE), a therapeutic …
examined the efficacy of cooling therapy in improving neurological outcomes after mild NE. …

… However, the efficacy varies in studies published to date, and some studies show no benefit
… therapy for neonates with evidence of moderate/severe encephalopathy attributable to …

… Such a wide gap in the efficacy of neuroprotective treatments between the experimental …
Independent variables which influence the efficacy of hypothermia have to be elucidated to …

… efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal
encephalopathy… A total of 218 term infants with moderate to severe neonatal encephalopathy …

… outcomes, and its 95% confidence interval. To determine whether the benefit of treatment
on outcomes was affected by the severity of encephalopathy… for Neonatal Encephalopathy …

… Non-neurological organ dysfunction not only has a negative effect on long term outcome
but may also influence the efficacy of treatments in the acute phase. Post resuscitative care …

… ]) and two neurologic findings of neonatal encephalopathy (abnormalities of tone, reflexes, …
Randomization procedures are detailed in the accompanying article on efficacy outcomes. …

… We suggest that clinical trials in the future be focused on defining the optimal degree and
duration of cooling and rewarming strategies as neuroprotection for neonatal encephalopathy. …