A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy

D Singh, P Kumar, A Narang - … Journal of Maternal-Fetal & Neonatal …, 2005 - Taylor & Francis
… of CSF findings suggestive of meningitis (1) and intracranial bleed/traumatic lumbar
puncture (14), leaving 25 babies in the phenobarbital group and 20 babies in the control group. …

Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia

L Filippi, G la Marca, G Cavallaro, P Fiorini, F Favelli… - …, 2011 - Wiley Online Library
… treat term newborns with hypoxicischemic encephalopathy, … Phenobarbital is widely used
to treat neonatal seizures, but it is … phenobarbital pharmacokinetics in asphyxiated newborns. …

A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxicischemic encephalopathy

LM Rao, SA Hussain, T Zaki, A Cho, T Chanlaw… - Epilepsy & Behavior, 2018 - Elsevier
… Seizures are common in term infants with hypoxicischemic encephalopathy (HIE) undergoing
therapeutic hypothermia. Although phenobarbital (PHB) is generally considered first-line …

Effect of phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy–a randomized controlled trial

D Singh, P Kumar, S Majumdar, A Narang - 2004 - degruyter.com
Phenobarbital on levels of oxidants and anti-oxidants in term and near term neonates with
hypoxic ischemic encephalopathy. … In Phenobarbital group (ns25), 5 babies died and 6 babies

Clinical pharmacology of phenobarbital in neonates: effects, metabolism and pharmacokinetics

GM Pacifici - Current pediatric reviews, 2016 - ingentaconnect.com
… used to treat term infants with hypoxic-ischemic encephalopathy. Filippi et al. [17… phenobarbital
administration may yield adverse effects in infants with hypoxic-ischemic encephalopathy

Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia

RA Shellhaas, CM Ng, CH Dillon… - Pediatric Critical Care …, 2013 - journals.lww.com
… of phenobarbital after accounting for weight and age. Standard phenobarbital dosing is …
in neonates with hypoxic ischemic encephalopathy treated with therapeutic hypothermia. …

Clinical, neuroimaging, and electrographic predictors of phenobarbital failure in newborns with hypoxic ischemic encephalopathy and seizures

D Dwivedi, N Lin, C Venkatesan… - Journal of Child …, 2019 - journals.sagepub.com
… Seizures initially treated with phenobarbital … Both cooled and uncooled neonates with
hypoxic ischemic encephalopathy and seizures were included in our study. Medical records were …

Phenobarbital for neonatal seizures: response rate and predictors of refractoriness

C Spagnoli, S Seri, E Pavlidis, S Mazzotta… - …, 2016 - thieme-connect.com
… had hypoxic-ischemic encephalopathy (29 showed a complete response to phenobarbital,
9 a … In summary, this study reports on the response rate to phenobarbital in newborns with …

Does phenobarbital improve the effectiveness of therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy?

S Sarkar, JD Barks, JR Bapuraj, I Bhagat… - Journal of …, 2012 - nature.com
… recovery in term or late preterm newborn infants after hypoxic-ischemic encephalopathy (HIE),
but it is not a ‘silver bullet’. Approximately one in nine infants (95% confidence interval 5 …

Treatment of hypoxic-ischemic encephalopathy in newborns

HC Glass, DM Ferriero - Current treatment options in neurology, 2007 - Springer
… of seizures in term infants is neonatal encephalopathy due to … phenytoin versus phenobarbital
for term infants with seizures … of prophylactic phenobarbital in 45 term infants with neonatal