… rate is lower in younger neonates compared with older infants. Although much is known
about morphine in neonates, further research will be required to ensure that recommended …

… Age- and therapy-related effects on morphine requirements and plasma concentrations
of morphine and its metabolites in postoperative infants. Br J Anaesth. 2003;90:642–52. …

… treatment has to be adjusted according to the requirements of each child, ie to the outcome
of morphine therapy. This is not easy as the end-point, a desired level of analgesia, can be …

… morphine metabolism in full-term newborns. After surgery neonates aged 7 days or younger
required fewer additional morphine doses, maintained higher plasma morphine levels, and …

… morphine requirements and plasma morphine concentrations. Significantly fewer neonates
required additional morphine doses compared with all other age groups and neonates had …

… was the most important factor affecting morphine requirements and plasma morphine
concentrations. Significantly fewer neonates required additional morphine doses compared with all …

… Morphine has a volume of distribution in preterm neonates that is higher than in term neonates
and older infants [1]. … in premature neonates, medications that do not require conversion, …

… ) in preterm newborns. Chay and colleagues 1 described a relationship between morphine
concentrations and the sedation required to tolerate artificial ventilation in 19 neonates, both …

… morphine requirements and plasma concentrations of morphine and its metabolites in
postoperative infants… The reduction of morphine requirements was lower than in our study (14% vs …

… neonates required much higher concentrations of morphine … morphine compared with adults,'
because neonates required … of morphine in infants, that neonates may require lower doses …