Nephron progenitor cells: shifting the balance of self-renewal and differentiation
… nephrons to regulate the formation of subsequent nephrons or the origin or role of vascular,
neural, and lymphatic progenitors … In this review, we will focus on the nephron progenitor …
neural, and lymphatic progenitors … In this review, we will focus on the nephron progenitor …
Role for compartmentalization in nephron progenitor differentiation
AC Brown, SD Muthukrishnan… - Proceedings of the …, 2013 - National Acad Sciences
… To screen for pathways that promote CITED1 + progenitor differentiation, we used the …
β-catenin activation promotes epithelial differentiation of nephron progenitor cells in cultured …
β-catenin activation promotes epithelial differentiation of nephron progenitor cells in cultured …
A synthetic niche for nephron progenitor cells
AC Brown, SD Muthukrishnan, L Oxburgh - Developmental cell, 2015 - cell.com
… nephron progenitor cell (NPC) renewal and differentiation. … to form tubules expressing nephron
differentiation markers. … mixture of cells with varying progenitor potential. Furthermore, we …
differentiation markers. … mixture of cells with varying progenitor potential. Furthermore, we …
Defining and redefining the nephron progenitor population
C Hendry, B Rumballe, K Moritz, MH Little - Pediatric Nephrology, 2011 - Springer
… not known about this nephron progenitor population and discuss … observed variation in final
nephron number and potentially … -renewal and differentiation into nephron epithelia is critical …
nephron number and potentially … -renewal and differentiation into nephron epithelia is critical …
Epigenetic States of nephron progenitors and epithelial differentiation
M Adli, M Parlak, Y Li… - Journal of cellular …, 2015 - Wiley Online Library
… nephron progenitors from pluripotent cells, which upon further differentiation provide a potential
source of new nephrons. … states of native nephron progenitors and their progeny. In this …
source of new nephrons. … states of native nephron progenitors and their progeny. In this …
Selective in vitro propagation of nephron progenitors derived from embryos and pluripotent stem cells
S Tanigawa, A Taguchi, N Sharma, AO Perantoni… - Cell reports, 2016 - cell.com
… , the progenitors terminally differentiate shortly after birth. Here, we report a method for selectively
expanding nephron progenitors in … bud induces differentiation of nephron progenitors ( …
expanding nephron progenitors in … bud induces differentiation of nephron progenitors ( …
Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system
M Kang, YM Han - PloS one, 2014 - journals.plos.org
… In this study, we developed a novel protocol for differentiation of nephron progenitor cells (…
usage aiming at damaged nephrons. In this study, we differentiated hPSCs into NPCs by step-…
usage aiming at damaged nephrons. In this study, we differentiated hPSCs into NPCs by step-…
Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation
… Collectively, our data suggest that Notch signaling primes nephron progenitors for
differentiation rather than directing their cell fates into proximal tubules. This work proposes a new …
differentiation rather than directing their cell fates into proximal tubules. This work proposes a new …
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man
… We show that either Fgf9 or Fgf20 is sufficient to maintain differentiation-competent, Six2+
nephron progenitors in vitro for 5 days, whereas cells grown in Fgf8 or Fgf10 lose competence …
nephron progenitors in vitro for 5 days, whereas cells grown in Fgf8 or Fgf10 lose competence …
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney
JL Fetting, JA Guay, MJ Karolak, RV Iozzo… - …, 2014 - journals.biologists.com
… two progenitor cell subtypes in Foxd1 -/- tissue. We found that although nephron progenitor
… , cortical interstitial cells prematurely differentiate. To identify pathways regulated by FOXD1, …
… , cortical interstitial cells prematurely differentiate. To identify pathways regulated by FOXD1, …
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