… of nephrogenesis, but there is no nephron generation in … not known about this nephron
progenitor population and discuss … the observed variation in final nephron number and potentially …

… Indeed, the periphery of the developing organ consists of a nephrogenic zone composed of
nephrogenic niches, each consisting of a ureteric tip surrounded by CM itself surrounded by …

… nephrogenesis is related to factors other than an intrinsic clock. This in vitro nephron progenitor
… that form at the outermost cortex within a progenitor cell niche known as the nephrogenic …

… Here, we focus on the mechanisms that modulate nephron numbers and/or the timing of
nephrogenesis cessation. We review the effect of environmental factors and the contributions of …

… populations is expected to improve our understanding of nephrogenesis and should
expedite a functional evaluation of their regenerative-medicine potential for treating adult …

… within the nephrogenic niche in the few days after birth. ► Loss of nephron progenitors
precedes the … We provide evidence for a gradual depletion of the nephron progenitor population. …

… progenitor cells and/or prolonged nephrogenesis beyond P3, when it normally ceases. We
found that a 40% reduction in the number of fetal nephron progenitor … the nephron progenitor …

… its conditional inactivation in nephron progenitor cells results in partial … nephrogenesis, but
with retention of PAX2 and WT1 expressing nephron progenitor cells within the nephrogenic …

… nephron progenitor cells and the decision to initiate nephrogenesis are crucial events directing
kidney … progenitors, fundamental questions about mechanisms driving expansion of the …

… of mouse kidney organ cultures. Single-cell RNA sequencing of the human nephrogenic
niche … adopted by nephron progenitor cells in forming segment-specific domains of the human …