… to induce nephron progenitors from both mouse and human … progenitors readily reconstitute
three-dimensional nephron … We can further generate human induced pluripotent stem cells (…

… Mature nephrons originate from a small population of uninduced nephrogenic progenitor …
Many studies on mouse models as well as on human pluripotent stem cells have advanced …

… Human nephron progenitor cells (hNPCs) have yet to be isolated. Here we show that growth
of human … isolation of NCAM1 + cells selects for nephron lineage that includes the SIX2‐…

… Furthermore, reducing toxicity by removing the need for multiple lentiviral constructs may
also improve reprogramming of primary human cells, for which our preliminary results suggest …

… marker expression pattern of both nephron stem/progenitors in hFK and cancer stem …
nephron stem cells. Similarly, we show that a the NCAM1 + CD133 − fraction of primary human WT …

… human pluripotent stem cells (hPSCs). In this study, we developed a novel protocol for
differentiation of nephron progenitor … Primary antibodies used in this study are described in Table …

… human pluripotent stem cells (hPSCs) into kidney structures. Our goal was to develop a
high-efficiency protocol to generate nephron progenitor … the desired primary antibodies. Incubate …

… determine nephron number are obscure. To test the importance of nephron progenitor cell
… this would limit kidney size and nephron number or whether compensatory mechanisms …

… with the exhaustion of nephron progenitor cells. Consequently, no nephrons are formed after
… function therefore depends on the complement of nephrons generated during gestation. In …

… hPSCs into multipotent nephron progenitor cells (NPCs) that can form nephron-like structures.
By … The cells were then incubated with primary antibody overnight at 4 C or for 2 h at RT in …