… differentiated nephrons. However, in mice, the progenitors terminally differentiate shortly
after birth. Here, we report a method for selectively expanding nephron progenitors in vitro in an …

… The CM is a unique mesenchymal progenitor/stem cell population and a critical driver of
branching morphogenesis and nephrogenesis. The CM is characterized at the molecular level …

… nephron structure in vitro. Many studies have tried to induce nephron progenitors from
pluripotent stem … the spatiotemporal origin of nephron progenitors, hampering our understanding …

… drive nephron formation within the developing kidney. Here, we document expression of the
adult stem … cells to developmental defects and for isolating human nephron progenitors as a …

… using stem cells have progressed rapidly in recent years. Our group has developed a protocol
to induce nephron progenitors from both mouse and human pluripotent stem cells which …

… kidney stem/progenitor cells (KS cells), derived from the S3 segment of adult rat kidney
nephrons, … Our results demonstrate that a cluster of tissue stem/progenitor cells has the ability to …

… This in vitro nephron progenitor niche will have important applications for expansion of cells
… The mature mouse kidney lacks an identifiable population of multipotent nephron stem cells …

… Model of approaches for the generation of nephron progenitors. This may include the
directed differentiation of human pluripotent stem cells (embryonic stem cells or induced …

… determine nephron number are obscure. To test the importance of nephron progenitor cell
… this would limit kidney size and nephron number or whether compensatory mechanisms …

Recapitulating three-dimensional (3D) structures of complex organs, such as the kidney,
from pluripotent stem cells (PSCs) is a major challenge. Here, we define the developmental …