… nephron progenitor population and discuss how an increased understanding of the regulation
of this population may better explain the observed variation in final nephron … to the stroma. …

… Recent transcriptional investigation of genes expressed in adjacent domains of cortical
stroma and nephron progenitors have identified both known and putative ligand-receptor pairs …

… Within the developing mammalian kidney, several populations of progenitors form the … ) to
be the progenitor population for all nephron epithelial cells, whereas the neighboring stromal …

… stroma interdigitates between the nephron progenitor caps and ureteric bud branches forming
the primary renal interstitium [5]. In the mature kidney, the renal stroma … The renal stroma …

… not only in nephron progenitors but also in stromal progenitors. Here … stromal progenitors
leads to aberrant expansion of nephron progenitors, which is in sharp contrast with a nephron …

… ureteric) ensures correct nephron progenitor self-renewal … in expansion of the mesenchymal
nephron progenitor pool, called … in the renal stroma to control nephron progenitors. We show …

… determine nephron number are obscure. To test the importance of nephron progenitor cell
… this would limit kidney size and nephron number or whether compensatory mechanisms …

… nephron progenitor cells (NPCs) and SPCs, called the interspecies dual replacement of the
progenitor (i… containing rat nephrons and stroma. This method can generate renal tissue from …

… Finally, we show that activation of β-catenin simultaneously in the nephron progenitor and
stromal lineages (using dual Six2cre and Foxd1cre expression) results in severely disrupted …

… Our observations also suggest that the Foxd1+ stromal progenitor and Six2+ nephron
progenitor populations temporally and spatially coordinate cellular differentiation. These data …