… We also observed ectopic expression of Wnt4 and premature tubule formation, similar to the
… However, our data suggest that premature Notch2 activation in nephron progenitors does …

… However, it does remain possible that a hierarchy of epithelial progenitors, acting in normal
tubular repair or able to be facultatively recruited under specific circumstances, also exists in …

… + nephron progenitors results in severe progenitor depletion and apoptosis of differentiating
nephrons [… Glomeruli and renal tubules generated in vitro from human iPSCs. The induced …

… of nephron progenitor cell number, we genetically ablated 40% of these cells, asking whether
this would limit kidney size and nephron … , epithelialization, tubular folding and elongation, …

… the progenitor population for all nephron epithelial … progenitors at the ureteric bud (UB) tip
and a proportion of the endothelium is also derived from a dedicated mesenchymal progenitor. …

… NPC cultures expanded up to one billion-fold in this environment can be induced to form
tubules expressing nephron differentiation markers. Single-cell culture reveals phenotypic …

… Because KS cells are derived from S3 segment of kidney proximal tubular cells, they should
originate from nephron progenitor cells present in the metanephric mesenchyme. Recently, …

… We found that 2 µM BIO causes vigorous epithelial tubule formation in E17.5 … .5 nephron
progenitors and that pure CITED1 + cells are competent to differentiate into epithelial tubules. …

… Interestingly, the existence of tubular progenitor cells was questioned by the use of lineage
tracing experiments in SLC3Aa1-CreERT2 mice, in which differentiated PTCs were terminally …

… Our findings provide crucial insight into how to generate nephron tubules in vitro for
potential cell replacement therapy. We have previously shown that Notch signaling in …