… It is now well recognized that podocin mutations are found in 10%–30% of sporadic cases …
nephrotic syndrome after renal transplantation in patients with podocin mutations is very low. …

… podocin (NPHS2), a truncation mutation in a compound heterozygous state with any other
podocin mutation, or the presence of two R138Q mutations… least one missense mutation (other …

… in association with other mutants NPHS2 allele or acting in synergism … podocin mutants
have shown that defects in cell sorting process predominate over structural alterations of podocin…

… mutations, with sequence variants, and with no podocin changes could not be distinguished
… , nephrotic syndrome in children with truncating or homozygous R138Q mutations manifests …

… podocin, different groups have demonstrated that mutations in the … In addition, mutations in
the NPHS2 gene were recently … Initial reports suggested that children with NPHS2 mutations …

… The clinical hallmark is nephrotic syndrome characterized by heavy proteinuria, edemas, …
such disorder is congenital nephrotic syndrome of the Finnish type (CNF), caused by mutations …

… episode of nephrotic syndrome should be tested for podocin mutation before … mutations.
Considering that 85% of children with INS are steroid-responsive and that podocin mutations are …

… Podocin has been shown to be highly expressed in the fetal … pattern consistent with congenital
nephrotic syndrome. It remains … findings in children with mutated NPHS2 might include the …

… In conclusion, the inducible R140Q-podocin mouse model is an auspicious model of …
nephrotic syndrome, with a spontaneous disease course strongly reminiscent of the human disorder…

… and podocin mutations in … podocin mutations compared with nephrin gene mutations.
Kaplan-Meier survival curve shows the proportion of patients who had NPHS1 or NPHS2 mutations …