An immunohistochemical study of nerve structures in the anulus fibrosus of human normal lumbar intervertebral discs

T Palmgren, M Grönblad, J Virri, E Kääpä, E Karaharju - Spine, 1999 - journals.lww.com
… A comparison between the results of the study by Ashton et al 1 and those of this study
shows that most nerve structures in clinically painless discs do not penetrate as deeply as into …

[PDF][PDF] Studies on structural changes in the lumbar annulus fibrosus

C Hirsch, F Schajowicz - Acta Orthopaedica Scandinavica, 1952 - Taylor & Francis
… only writers who have found nerve fibres in the annulus fibrosus, further investigations on this
… a size that they penetrate the greater part of the annulus fibrosus bring about the formation …

Nerve ingrowth into diseased intervertebral disc in chronic back pain

AJ Freemont, TE Peacock, P Goupille, JA Hoyland… - The lancet, 1997 - thelancet.com
nerve fibres in the outer third of the annulus fibrosus in 48 (60%) of the 80 samples of
intervertebral discs. Nerves … Blood vessels penetrated into the middle third of the annulus fibrosus

Penetrating annulus fibrosus injuries affect dynamic compressive behaviors of the intervertebral disc via altered fluid flow: an analytical interpretation

AJ Michalek, JC Iatridis - 2011 - asmedigitalcollection.asme.org
… This study provides a quantitative hypothetical model of how penetrating annulus fibrosus
injuries in discs with a gelatinous nucleus pulposus may alter disc mechanics by changing …

Biologic Annulus Fibrosus Repair: A Review of Preclinical In Vivo Investigations

SR Sloan Jr, M Lintz, I Hussain, R Hartl… - … Engineering Part B …, 2018 - liebertpub.com
… lesions in the annulus fibrosus (AF) and impinges on the spinal cord and surrounding nerves.
… Furthermore, scaffolds must penetrate the full thickness of the AF to facilitate total annular

The nerve supply of the lumbar intervertebral disc

MA Edgar - The Journal of Bone & Joint Surgery British Volume, 2007 - boneandjoint.org.uk
nerve endings in the degenerative lumbar disc penetrate deep … Complex as well as free
nerve endings would appear to … of the annulus fibrosus, 10 , 13 and to the anterior dura. Some …

Tensile properties of the annulus fibrosus: I. The contribution of fibre-matrix interactions to tensile stiffness and strength

MA Adams, TP Green - European Spine Journal, 1993 - Springer
… do radial fissures often reach, but not penetrate, the outermost 1-2 mm of the annulus [4, 6]? …
is protected from extreme bending by the ligaments of the neural arch [5]. Vertical force and …

[HTML][HTML] Multifunctional annulus fibrosus matrix prevents disc-related pain via inhibiting neuroinflammation and sensitization

Y Peng, X Chen, Z Rao, W Wu, H Zuo, K Chen, K Li… - Acta biomaterialia, 2023 - Elsevier
… and nerve growth factor (NGF) that induce nerve growth into the inner annulus fibrosus, …
Sensory nerve fibers penetrate the ECM into the inner AF and nucleus pulposus (NP) [16]. …

[PDF][PDF] In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs

A Nachemson, T Lewin, A Maroudas… - Acta Orthopaedica …, 1970 - Taylor & Francis
… of connective tissue scarring around the nerve roots. In other … through the end-plates and the
annulus fibrosus, and (2) to … of the structure, eventual penetration of the annulus even in the …

[HTML][HTML] Effects of annulus defects and implantation of poly (lactic-co-glycolic acid)(PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury …

L Xin, W Xu, L Yu, S Fan, W Wang, F Yu… - Journal of orthopaedic …, 2017 - Springer
… of nerve fibers in the inner layers of the annulus fibrosus (AF) and … nerve ingrowth via AF
defect. Therefore, unsealing of the annulus wall appears to facilitate a deeper nerve penetration; …