Axon regeneration through scaffold into distal spinal cord after transection

BK Chen, AM Knight, GCW De Ruiter… - Journal of …, 2009 - liebertpub.com
… the scaffold and cord sectioned longitudinally (30 μm) on a cryostat. Trans-scaffold labeling
of neuron … Large (30–50 μm diameter) neuron cell bodies were predominantly labeled in the …

Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

YD Teng, EB Lavik, X Qu, KI Park… - Proceedings of the …, 2002 - National Acad Sciences
… To better direct repair following spinal cord injury (SCI), we designed an implant modeled
after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural

Graft of a tissue-engineered neural scaffold serves as a promising strategy to restore myelination after rat spinal cord transection

BQ Lai, JM Wang, EA Ling, JL Wu… - Stem cells and …, 2014 - liebertpub.com
… of 3D GS scaffolds, NSCs in the engineered neural scaffold can be effectively … neural
network scaffold would support myelination at the lesion gap following spinal cord transection

Neural stem cell–and schwann cell–loaded biodegradable polymer scaffolds support axonal regeneration in the transected spinal cord

HE Olson, GE Rooney, LA Gross, JJ Nesbitt… - … Engineering Part A, 2009 - liebertpub.com
scaffold and quantitatively assesses their potential to promote regeneration after a spinal
cord transection injury in … Rats with transection injuries received scaffold implants containing …

Developing a mechanically matched decellularized spinal cord scaffold for the in situ matrix-based neural repair of spinal cord injury

Y Ma, H Shi, Q Wei, Q Deng, J Sun, Z Liu, B Lai, G Li… - Biomaterials, 2021 - Elsevier
… DSC scaffolds encourage endogenous neurogenesis at the injury/graft site, which may
contribute to the formation of a neuronal … signals to pass through the injury area [[35], [36], [37]]. …

[HTML][HTML] Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation

X Li, D Liu, Z Xiao, Y Zhao, S Han, B Chen, J Dai - Biomaterials, 2019 - Elsevier
… spinal cord transection research in general include implanting artificial neural scaffolds or
… cells (eg, olfactory ensheathing glia, neural stem cells, mesenchymal stem cells, and human …

[HTML][HTML] Anisotropic scaffolds for peripheral nerve and spinal cord regeneration

W Xue, W Shi, Y Kong, M Kuss, B Duan - Bioactive materials, 2021 - Elsevier
… nerves and spinal cords as well as critical requirements for regenerative scaffold designs. …
methods and recent advances of anisotropic nerve scaffolds from multidimensional aspects, ie …

3D bioprinted neural tissue constructs for spinal cord injury repair

X Liu, M Hao, Z Chen, T Zhang, J Huang, J Dai… - Biomaterials, 2021 - Elsevier
neural constructs with anatomically accurate complex geometries and spatial distributions of
neural stem cells (NSCs) for spinal cord injury (… fabricate a neural tissue scaffold that mimics …

Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair

Y Zou, D Ma, H Shen, Y Zhao, B Xu, Y Fan, Z Sun… - Biomaterials …, 2020 - pubs.rsc.org
transection spinal cord injury model used in our study might result in this. To ensure that the
axon at the lesion … a 2 mm-long section of the spinal cord during operation. Different from the …

A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair

W Liu, B Xu, W Xue, B Yang, Y Fan, B Chen, Z Xiao… - Biomaterials, 2020 - Elsevier
Scaffolds containing parallel microchannels can guide directional axon growth and … the
bundles of nerve fibers found in spinal cord tissue, we designed a scaffold material with an …