The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons

SA Mahoney, R Hosking, S Farrant… - Journal of …, 2003 - Soc Neuroscience
neurite outgrowth from cultured mutant DRG neurons. Here, we show that the addition of
galanin peptide significantly enhanced neurite outgrowth … Furthermore, neurite outgrowth in wild…

Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour

SA Hobson, FE Holmes, NCH Kerr… - Journal of …, 2006 - Wiley Online Library
Galanin also plays a trophic role in the adult animal, and the rate of peripheral nerve regeneration
and neurite outgrowth is … a one third reduction in neurite outgrowth from cultured DRG …

Galanin stimulates neurite outgrowth from sensory neurons by inhibition of Cdc42 and Rho GTP ases and activation of cofilin

SA Hobson, PA Vanderplank, RJP Pope… - Journal of …, 2013 - Wiley Online Library
galanin receptor subtypes mediate the effects of galanin, we studied GalR2-KO animals,
demonstrating a marked reduction in neurite outgrowth … The addition of galanin (which also …

Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase

JJ Hawes, R Narasimhaiah… - European Journal of …, 2006 - Wiley Online Library
… The expression of galanin receptors in PC12 cells and hippocampal neural progenitor cells
was verified by real-time PCR (Fig. 1). Both cell types used in this study expressed GalR1, …

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain

E Keimpema, K Zheng, SS Barde, P Berghuis… - Cerebral …, 2014 - academic.oup.com
galanin receptor 2 (GalR2) in the neonatal mouse basal forebrain, develops by birth. Nerve
… We hypothesized that GalR2 activation couples to neurite outgrowth in cholinergic neurons. …

Galanin promotes neuronal differentiation in murine subventricular zone cell cultures

F Agasse, S Xapelli, V Coronas… - Stem cells and …, 2013 - liebertpub.com
… for galanin receptor 2 have decreased neurite outgrowth from … for galanin receptor 2 have
decreased neurite outgrowthgalanin receptor GalR2 plays a key role in neurite outgrowth from …

Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour

TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
… of this receptor subtype to the role of galanin at the spinal level… , including galanin,
neuropeptide Y and two of its receptors as … system, suggesting that galanin actions mediated by …

The role of galanin as a multi-functional neuropeptide in the nervous system

D Wynick, SWN Thompson, SB McMahon - Current opinion in …, 2001 - Elsevier
… delayed neurite outgrowthgalanin receptor subtypes at some point in their development.
Miller et al. [46] failed to demonstrate co-localisation of the mRNA for the first galanin receptor

Galanin acts as a trophic factor to the central and peripheral nervous systems

SA Hobson, A Bacon, CR Elliot-Hunt, FE Holmes… - Galanin, 2010 - Springer
… protein-coupled galanin receptor subtypes designated GalR1… that produce neurites is reduced
by a one third, and neurite … in neurite outgrowth can be rescued by the addition of galanin

Galanin receptors as a potential target for neurological disease

K Freimann, K Kurrikoff, Ü Langel - Expert Opinion on Therapeutic …, 2015 - Taylor & Francis
… seems to be an important element in AD pathophysiology and recent results favor galanin’s
role in the protection of CBF neuron function, which may delay the onset of symptoms of AD …