… Therapeutic approaches that are directed at single biological mechanisms or targets may
be inadequate, given the complexity of these multifaceted neurodegenerative disorders. …

… Imaging biomarkers play a wide-ranging role in clinical trials for neurological disorders.
This includes selecting the appropriate trial participants, establishing target engagement and …

… Researchers speculate that neurodegenerative disorders, including Alzheimer’s … may be
used to evaluate treatment effects in future clinical trials. This study is not yet recruiting and the …

… for future clinical trials in neurodegenerative disorders. Given the high unmet need for
effective treatment and high futility rates of previous trials, we believe that future trials should …

… spinocerebellar ataxias (please see clinicaltrials.org). The aim of this review is to assemble
the published clinical trials of lithium on neurological and neurodegenerative conditions, and …

… demonstrated in clinical trials by a drug-placebo difference in clinical outcomes supported …
a staggered start or delayed withdrawal clinical trial design. Collecting multiple biomarkers is …

… clinical trials for NDDs registered on clinicaltrials.gov in the past 10 years. We identified 59
basket trials … We describe drugs in clinical trials for multiple NDDs. Drugs in this category were …

… in neurodegenerative disorders from the existing literature, from ongoing clinical trials, and
… of pharmaceutical companies involved in trials of neurodegenerative diseases. Our objective …

… However, clinical translations of mitochondrial treatments … enter clinical trials when their
neurodegenerative disorders are … gene therapy for neurodegenerative disorders continues to be …

… strategies against neurodegenerative disorders, that pause neurodegeneration rather than
… against neurodegenerative disorders. A recent search in ongoing clinical trials revealed less …