… linked to the pathogenesis of neurodegenerative disorders. In this review we mainly focus
on mitochondrial dysfunction in two of the most prevalent neurological disorders: Alzheimer’s …

… no doubt that oxidative species and mitochondria are playing important roles in NDDs. This
review discusses the effects of the oxidative stresses and mitochondrial dysfunction in NDDs. …

… It is possible therefore that mitochondrial dysfunction in the neurodegenerative disorders
may result in a … In any event, mitochondria present an important target for future strategies for ‘…

… -mentioned neurodegenerative disorders, increased … in neurodegenerative disorders is
the degree of mitochondrial DNA damage and the maintenance of an appropriate mitochondrial …

… dysfunction and loss. With ever-increasing numbers of papers being published in the field of
mitochondria and neurodegenerative … , particularly into mitochondrial degradation. We hope …

… is well known in all of the major neurodegenerative disorders; therefore, therapies targeting
the Nrf2/antioxidant response element (ARE) pathway are of particular interest. Synthetic …

… of the mitochondrial permeability transition and secondary excitotoxicity. Neurodegenerative
diseases of widely disparate genetic etiologies may share mitochondrial dysfunction as a …

… mitochondrial dysfunction in selected neurodegenerative … Mitochondria undoubtedly play
an important role in human … other disorders will be attributed to mitochondrial dysfunction. The …

… First, what is the basis for cell-type specificity in neurodegenerative disorders? For example,
why does systemic overexpression of mutant SOD1 affect calcium handling in brain but not …

… rely on optimal mitochondrial function, as mitochondrial ATP production is … mitochondrial
dysfunction contributes significantly to neuronal injury in a host of neurodegenerative disorders, …