… of the PERK pathway may hold promise in a wider variety of neurodegenerative diseases. …
of neurodegeneration, further study into safer PERK inhibition strategies should be pursued. …

… neurons and have also been linked to the UPR and PERK pathway. Parkinson’s disease
(PD) is a neurodegenerative disorder characterized by the deposit of ubiquitinated α-synuclein …

… HD is a neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), …
UPR pathway induced was the PERK pathway [60]. As in other neurodegenerative diseases, …

… used treatments against the aforementioned neurodegenerative disorders may only alleviate
… that the inhibition of the PERK-dependent UPR signaling pathways may constitute a novel …

… neurodegenerative diseases based on oxidative stress and cell death pathways with emphasis
on the role of PERK… in various disorders, including neurodegenerative disorders, cancer, …

… systemic disorders with the UPR, but with a specific emphasis on the PERK pathway. Then,
… UPR, and more specifically PERK, and neurodegenerative disorders are presented. Finally, …

… Given that dysregulation of the PERK/eIF2α pathways likely represents a common crucial
pathological feature in neurodegenerative diseases [9] and has been well linked to cognitive …

… AD is a progressive neurodegenerative disorder pathologically characterized by the
accumulation of amyloid plaques and neurofibrillary tangles, composed of amyloid-beta peptides (…

… More importantly, genetic and pharmacological manipulations of PERK signaling have
revealed multiple mechanisms in which the overactivation of PERK-eIF2α pathways is a hub for …

… Once activated, PERK initiates signalling pathways that halt … In this review, we address the
molecular mechanisms by which PERK … PERK in neurodegenerative and metabolic diseases. …