Impairments in dendrite morphogenesis as etiology for neurodevelopmental disorders and implications for therapeutic treatments

T Copf - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
neurodevelopmental disorders, with focus on autism and schizophrenia. We next discuss
high-risk genes for these disorders and their role in dendrite morphogenesis. … relate to dendrite

Plasticity of dendritic spines: Molecular function and dysfunction in neurodevelopmental disorders

J Nishiyama - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
… in dendritic spine shape, size, and density have been implicated in many neurodevelopmental
disorders… (ID), suggesting that dendritic spine dysfunction is a common pathomechanism. …

Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models

V Martínez‐Cerdeño - Developmental neurobiology, 2017 - Wiley Online Library
… FMRP has been shown to interact in vitro with p21-activated kinases (PAK), an enzyme
known to play a critical role in actin polymerization and dendritic spine morphogenesis. The …

… of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental …

CA Chapleau, JL Larimore, A Theibert… - … of neurodevelopmental …, 2009 - Springer
… of axonal and dendritic differentiation, and in dendritic spine morphogenesis. Several genes
that are either mutated or deregulated in neurodevelopmental disorders associated with …

The dendritic tree and brain disorders

VA Kulkarni, BL Firestein - Molecular and Cellular Neuroscience, 2012 - Elsevier
Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendriteneurodevelopmental disorders, …

Molecular mechanisms of dendrite morphogenesis

J Arikkath - Frontiers in cellular neuroscience, 2012 - frontiersin.org
… that regulate dendrite morphogenesis, particularly in cortical … of aberrant dendritic morphology
for human disease. Finally, we … for neurodevelopmental disorders and acute neurological …

Regulation of dendrite morphogenesis by extrinsic cues

P Valnegri, SV Puram, A Bonni - Trends in neurosciences, 2015 - cell.com
… of dendrite development. We also highlight how extrinsic cues influence local and global
intracellular mechanisms of dendrite morphogenesis. Finally, … of neurodevelopmental disorders. …

Cadherins and catenins in dendrite and synapse morphogenesis

E Seong, L Yuan, J Arikkath - Cell adhesion & migration, 2015 - Taylor & Francis
… been implicated in a variety of neurodevelopmental disorders. In this review, we … of dendrite
and synapse architecture and function and their relevance to human neurological disorders. …

Molecular mechanisms that mediate dendrite morphogenesis

JL Lefebvre - Current topics in developmental biology, 2021 - Elsevier
… and are implicated in neurodevelopmental disorders. In this … of dendritic morphologies is
produced in nervous systems. In this chapter, I review mechanisms of dendrite morphogenesis

Current best practices for analysis of dendritic spine morphology and number in neurodevelopmental disorder research

BZ Li, A Sumera, SA Booker… - ACS Chemical …, 2023 - ACS Publications
… Indeed, while this Perspective focuses on neurodevelopmental disorders, dendritic spine …
neurodegenerative disorders such as Alzheimer’s disease and dementia, (31,32) Huntington’s …