… MEN1 syndrome is characterised by the occurrence of primary tumours involving two or
more endocrine tissues within a single patient. It encompasses tumours of the parathyroids (95% …

… Pituitary tumors in patients with multiple endocrine neoplasia type 1 syndrome tend to be …
multiple endocrine neoplasia type 1. Pituitary Neoplasms; Multiple Endocrine Neoplasia Type 1…

… MEN1 is an autosomal dominant disorder that is due to mutations in the tumor suppressor
gene MEN1, which … Thus, the finding of MEN1 in a patient has important implications for family …

… endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary tumor syndrome
… tumor suppressor gene MEN1, and is characterized by a predisposition to a multitude of …

… MEN1 disease. However, in another study, heterozygous mice (+/−) surprisingly died as
embryos in late gestation, with some embryos developing omphaloceles. Homozygous (−/−) …

… syndromes, such as multiple endocrine neoplasia type 1 (MEN-1 syndrome) and multiple
endocrine neoplasia type 2 syndrome (MEN-2 syndrome), as well as von Hippel Lindau (VHL) …

… to present an update about MEN1 and MEN2 syndromes. Clinical picture of MEN syndromes
… Pituitary tumors could be the first manifestation of the MEN1 syndrome and occur more …

… neoplasms appearing in at least ten genetic syndromes. The most important one is multiple
endocrine neoplasia type 1 (MEN-1), caused by mutations in the tumour suppressor … MEN1. …

… molecular details of the MEN1 and MEN4 syndromes. The gene causing … MEN1 associated
endocrine tumor is generally similar to that for the respective tumors occurring in non-MEN1 …

… Other endocrine and non-endocrine neoplasms including … MEN1 gene was identified
by positional cloning, and mutations in MEN1 were confirmed to cause the MEN1 syndrome …