… of neoplasms appearing in at least ten genetic syndromes. The most important one is
multiple endocrine neoplasia type 1 (MEN-1), caused by mutations in the tumour suppressor …

… diagnosis and treatment of MEN1-associated tumors, patients with MEN1 continue to have
… to malignant neuroendocrine tumors. The most recent clinical practice guidelines for MEN1, …

… endocrine tumors are the most common MEN-1–related cause of death in MEN-1 kindreds
[3… and pancreas in patients with MEN-1 demonstrates multiple neuroendocrine tumors [11,12]. …

… MEN1 is defined as the development of two or more tumors from the main three endocrine
… /duodenum/foregut area (termed pancreatic neuroendocrine tumors [PNET] in this review for …

… MEN1 is a rare genetic disorder that predisposes patients to primary hyperparathyroidism,
duodenopancreatic neuroendocrine tumours and anterior pituitary tumours, as well as more …

… of MEN1 usually includes the presence of at least two neuroendocrine tumors affecting the
… gland or by the occurrence of one of these three main tumors plus one first-degree relative …

… of tumors of the parathyroid glands, pancreatic islet cells, and anterior pituitary gland. MEN
1 is … primarily to malignant pancreatic neuroendocrine tumors and fore-gut carcinoids. The …

… The prognosis for MEN1 patients might be improved by presymptomatic tumor detection
and undertaking treatment specific for MEN1 tumors. Thus, it is recommended that MEN1 …

… neoplasia type 1 is an autosomal dominant disorder classically characterized by neuroendocrine
tumors … , menin, caused by mutations in the MEN1 gene on 11q13. Clinically, patients …

… In fact, early detection and treatment of the potential malignant neuroendocrine tumours
should reduce the morbidity and mortality of MEN1 syndrome. Such screenings can detect the …