The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure

M Packer - Journal of the American College of Cardiology, 1992 - Elsevier
… formulation of the neurohormonal hypothesis of heart failure. … ‘The first clinical te5t of the
neurohormonal hypothesis was !… reduce the risk of disease progression and thus prolong life in …

Evolution of the neurohormonal hypothesis to explain the progression of chronic heart failure

M Packer - European heart journal, 1995 - academic.oup.com
… of patients provides strong support for the neurohormonal hypothesis of heart failure. … The
neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart …

Neurohormonal activation and progression of heart failure: hypothetical and clinical considerations

GS Francis - Journal of Cardiovascular Pharmacology, 1998 - journals.lww.com
… ) blockers have the potential to slow the progression of LV remodeling, and ample clinical
data in support of the neurohumoral hypothesis are now available. However, the mechanisms …

[PDF][PDF] Neurohormonal hypothesis in heart failure

DN Tziakas, GK Chalikias, DI Xatseras - Hellenic J Cardiol, 2003 - hellenicjcardiol.org
… Two are the main key points of the neurohormonal hypothesis… mechanisms accordingly to
neurohormonal hypothesis is not … the neurohormonal hypothesis to explain the progression of …

Basic mechanisms in heart failure: the cytokine hypothesis

Y Seta, K Shan, B Bozkurt, H Oral, DL Mann - Journal of cardiac failure, 1996 - Elsevier
… Packer M: The neurohormonal hypothesis: a theory to explain the mechanism of disease
progression in heart failure. J Am Coll Cardiol 1992;20:248-54 2. Kagan BL, Baldwin RL, …

Psychosocial and neurohormonal predictors of HIV disease progression (CD4 cells and viral load): a 4 year prospective study

G Ironson, C O'cleirigh, M Kumar, L Kaplan, E Balbin… - AIDS and Behavior, 2015 - Springer
neurohormones did not mediate the relationship between psychosocial variables and disease
progression, as hypothesized … correlated significantly with the neurohormones. While this …

Immune and neurohormonal pathways in chronic heart failure

R Sharma, SD Anker - Congestive Heart Failure, 2002 - Wiley Online Library
… that the progression of heart failure is due to neurohormonalneurohormonal hypothesis,
49 HF progresses due to the deleterious effects of the activated endogenous neurohormonal

Neurohormonal upregulation in heart failure

WHW Tang, GS Francis - Heart failure clinics, 2005 - heartfailure.theclinics.com
… The neurohormonal hypothesis: a theory to explain the mechanism of disease progression
… One could argue that the neurohormonal hypothesis has been too descriptive or more akin to …

Neurohormonal activation in heart failure with reduced ejection fraction

J Hartupee, DL Mann - Nature Reviews Cardiology, 2017 - nature.com
neurohormonal activation drives the progression of HFrEF. … Therefore, although the
neurohormonal hypothesis has … model does not fully explain disease progression. Indeed, …

Neurohormones, inflammatory mediators, and cardiovascular injury in the setting of heart failure

L Grosman-Rimon, F Billia, E Wright, S Carasso… - Heart Failure …, 2020 - Springer
… of neurohormonal activation, which can reduce morbidity and mortality related to this
condition. Beyond benefits associated with neurohormonal … involved in disease progression. …