[HTML][HTML] Neurokinin-1 receptor as a potential drug target for COVID-19 treatment

R Mehboob - Biomedicine & Pharmacotherapy, 2021 - Elsevier
… In most complicated cases of COVID-19 infection, the clinical manifestations included fever,
… SP via its tachykinin receptor, NK-1R is responsible for inflammation in COVID-19 infection. It …

… as a combinant with Dexamethasone reduces the inflammation via Neurokinin 1 Receptor Antagonism in severe to critical Covid-19 patients and potentiates …

R Mehboob, FJ Ahmad, A Qayyum, MA Rana… - Medrxiv, 2020 - medrxiv.org
… the initiation of cytokine storming developed in Covid-19 infection and we suggest Neurokinin-1
Receptor antagonist, Aprepitant, as a drug to be used for its treatment. It may help in the …

[PDF][PDF] … as a combinant with Dexamethasone reduces the inflammation via Neurokinin 1 Receptor Antagonism in severe to critical Covid-19 patients and potentiates …

R Mehboob, FJ Ahmad, A Qayyum, MA Rana, S Amir - scholar.archive.org
… the initiation of cytokine storming developed in Covid19 infection and we suggest Neurokinin-1
Receptor antagonist, Aprepitant, as a drug to be used for its treatment. It may help in the …

[HTML][HTML] Substance P/Neurokinin-1 receptor, trigeminal ganglion, latency, and coronavirus infection-is there any link?

R Mehboob, M Kurdi, A Bamaga, N Aldardeir… - Frontiers in …, 2021 - frontiersin.org
… , may be used to alleviate the symptoms and treat this infection by blocking this nociceptive
… SP/ Neurokinin 1-Receptor may serve as a potential therapeutic strategy against COVID-19

Neurokinin 1 receptor antagonism as a possible therapy for alcoholism

DT George, J Gilman, J Hersh, A Thorsell, D Herion… - Science, 2008 - science.org
… (19). In agreement with these earlier observations, we found that placebo-treated alcoholics
… In addition, the LY686017-treated group showed greater brain activation to the positive …

[HTML][HTML] Tachykinins and the potential causal factors for post-COVID-19 condition

SJ Janket, DD Fraser, AE Baird, F Tamimi… - The Lancet …, 2023 - thelancet.com
… The antagonism of tachykinins receptors can be a potential treatment target. … , neuropeptide
γ, haemokinin-1, and endokinins. Tachykinin neurokinin 1 receptors are widely distributed in …

Dexamethasone-sparing on days 2–4 with combined palonosetron, neurokinin-1 receptor antagonist, and olanzapine in cisplatin: a randomized phase III trial …

H Minatogawa, N Izawa, K Shimomura… - British Journal of …, 2024 - nature.com
care recommends a reduced dose of DEX on day 1 without … patients receiving HEC during
the COVID-19 pandemic [25]. … by Cancer Care Ontario in Canada during the COVID-19

[HTML][HTML] The rationale for angiotensin receptor neprilysin inhibitors in a multi-targeted therapeutic approach to COVID-19

A Bellis, C Mauro, E Barbato, B Trimarco… - International Journal of …, 2020 - mdpi.com
… for COVID-19 and to examine the data supporting the potential benefits of SAC/VAL in
COVID-19 treatment. … SAC/VAL therapy on COVID-19 severity. We expect a reduced severity of …

Neurokinin 1 receptor isoforms and the control of innate immunity

F Tuluc, JP Lai, LE Kilpatrick, DL Evans… - Trends in …, 2009 - cell.com
… Two naturally occurring variants of the neurokinin 1 receptor (NK1R) mediate the effects
of SP: a ‘classic’ full-length receptor and a truncated (tail-less) form that lacks 96 amino acid …

[HTML][HTML] The role of Neuropilin-1 in COVID-19

BS Mayi, JA Leibowitz, AT Woods, KA Ammon… - PLoS …, 2021 - journals.plos.org
… with severe Coronavirus Disease 2019 (COVID-19) showed … cells, but not uninfected
cells [1]. It remains to be seen … 1 could be an effective therapy in the fight against COVID-19. …