Discrepancy between neurokinin 1 receptor antagonist treatment and neurokinin 1 receptor knockout mice in the CD8 T cell response to corneal HSV-1 infection

A Jerome, S Suvas - The Journal of Immunology, 2018 - journals.aai.org
… The purpose of this study is to evaluate the effect blocking neurokinin 1 receptor (NK1R)
signaling has on the CD8 T cell response to corneal herpes simplex 1 (HSV-1) infection, using …

[HTML][HTML] Efficacy of neurokinin-1 receptor antagonists in the prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in patients receiving carboplatin-based …

M Di Maio, C Baratelli, P Bironzo, F Vignani… - Annals of …, 2017 - annalsofoncology.org
Care in Cancer (MASCC) for chemotherapy-induced nausea and vomiting (CINV), a combination
of a NK1 receptor … of emesis for patients treated with carboplatin-based chemotherapy. …

[PDF][PDF] On the role of “substance P” in the respiratory tract in corona infections to the causes of corona-related brain destruction

R Mehboob, P Oehme, G Pfaff - Leibniz Online, 2023 - leibnizsozietaet.de
… belongs to the group of neurokinins, the COVID-19 infection, and air … These effects are
independent of the NK 1 receptor. … , for the therapy of severe COVID courses. Mehboob proposed …

[HTML][HTML] Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19). For this reason, many researchers have tried to
implement therapies to mitigate the cytokine storm in the treatment of COVID-19 … in COVID-19

GPCR large-amplitude dynamics by 19F-NMR of aprepitant bound to the neurokinin 1 receptor

B Pan, D Liu, L Yang… - Proceedings of the …, 2022 - National Acad Sciences
… used 19 F-NMR observation of aprepitant, which is an approved drug that targets NK1R for
the treatment … health officials with early warnings for new COVID-19 outbreaks, but to date, no …

Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer

E Gillespie, SE Leeman, LA Watts… - Proceedings of the …, 2011 - National Acad Sciences
… the proinflammatory and mitogenic neurokinin-1 receptor (NK-1R)… truncated (tr-NK-1R) and
full-length (fl-NK-1R) receptors by … NK-1R may play a functional role in the disease; treatment

Substance P–a regulatory peptide with defense and repair functions. Results and perspectives for the fight against COVID-19

R Mehboob, P Oehme, T Anwar, JP von Kries - Frontiers in Neurology, 2024 - frontiersin.org
… Furthermore, we propose a new therapeutic approach for the prevention and treatment of
COVID-19 disease: the combination of an NK-1R inhibitor and the glucocorticoid …

COVID19, nausea, and vomiting

PLR Andrews, W Cai, JA Rudd… - … of gastroenterology and …, 2021 - Wiley Online Library
treatments (eg 5-HT 3 and NK 1 receptor antagonists). Further studies of mechanisms are
needed and in addition to in vitro studies of EEC cell lines these may include studies in the …

[HTML][HTML] COVID-19 treatment options: a difficult journey between failed attempts and experimental drugs

A Bartoli, F Gabrielli, T Alicandro, F Nascimbeni… - Internal and emergency …, 2021 - Springer
COVID-19 treatment options which are currently under investigation. For each drug deemed
to be potentially effective on COVID-19 … -2 or may affect COVID-19 pathogenesis, then we …

Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor

S Spitsin, F Tuluc, J Meshki, J Ping Lai… - …, 2013 - karger.com
… analgesic activity most likely mediated through the blockade of neurokinin-1 receptor (NK1R),
the substance P (SP)-preferring receptor. The ability of vapreotide to interfere with other …