… ) while neuromyelitis optica (NMO) is an inflammatory disease of the CNS that selectively
affects the optic nerves … Possible mechanisms for NMO and OSMS are discussed in this review. …

… pathogenesis mechanisms of the AQP4-based neuroinflammatory disease, neuromyelitis
optica (… However, there are clear differences in the sites and pathology of lesions, and in their …

… However, internalisation of AQP4, a process that could paradoxically protect astrocytes from
immune mediated cytotoxicity, is unlikely to be the principal pathogenic mechanism in NMO. …

… humoral immunity in the pathogenesis of NMO. Proposed pathogenic mechanism in NMO
… , we speculate on several mechanisms that may be involved in NMO pathogenesis. The …

… role of eosinophils in NMO pathogenesis and the therapeutic … mediated cytotoxicity (CDCC)
mechanism. NMO pathology was … NMO pathogenesis by ADCC and CDCC mechanisms and …

… reflective of a different primary immunopathogenic mechanism between the diseases. …
This could be explained if the inciting pathogenic mechanism originates outside of the CNS and …

… The pathogenetic mechanisms in NMO are radically different in patients with established
lesions, and so, therefore, should be the therapeutic intervention. Astrocytes are lost in large …

… a pathogenic role of AQP4-IgG … mechanisms of neuropathology. Herein, we review the
major clinical aspects of NMO ON, recent progress in elucidating NMO pathogenesis mechanisms…

… acute optic neuritis and transverse myelitis. In most patients, NMO is caused by pathogenetic
… In a subset of patients negative for AQP4-IgG, pathogenetic serum IgG antibodies to myelin …

… and recurrent attacks of optic neuritis and longitudinally extensive … that AQP4 antibody is
pathogenic, resulting in selective … insights into the pathogenic mechanisms, cellular targets, as …