… Mutations in TDP-43 cause motor neuron degeneration and ALS [28, 29]. The overwhelming
majority of the mutations are located in the C-terminal glycine-rich domain [12], which is …

… of TDP-43 depletion in postnatal mammalian neurons have not … generated motor
neuron-specific TDP-43 knockout (TDP CKO… effects of TDP-43 loss on postnatal motor neurons in …

… similar TDP-43 pathological manifestations in neurons and … , ubiquitinated or
hyperphosphorylated TDP-43 inclusions in … degeneration of motor neurons remains debatable. …

… TDP-43 nuclear protein is involved in several major neurodegenerative diseases that include
frontotemporal lobar degeneration … In the neuronal tissues of affected individuals TDP-43 …

… and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if
cortical neurons detected by NeuN decreased with increasing TDP-43 inclusion pathology in …

… in cortical neurons. Our data … TDP-43 results in loss of normal TDP-43 function(s) and gene
regulatory pathways, culminating in degeneration of selectively vulnerable affected neurons. …

… Loss of normal function of TDP-43 leads to neuronal degeneration. … in the TDP-43 gene
cause ALS. A major unresolved question is whether TDP-43-mediated neuronal loss is caused …

… -negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
… We also propose a model in which loss-of-function of TDP-43 in neurons might contribute to …

… Aggregation of misfolded TAR DNA-binding protein 43 (TDP-43) is a striking hallmark of …
lobar degeneration (FTLD) or amyotrophic lateral sclerosis (ALS). A direct causal link with …

… , accumulation and ubiquitination of TDP-43 in the cytoplasm of human motor neurons are
early dysfunctions in the cascade of the events leading to motor neuron degeneration in ALS, …