STLV-1 Commonly targets neurons in the brain of asymptomatic non-human primates

B Rocamonde, S Alais, R Pelissier, V Moulin… - Mbio, 2023 - Am Soc Microbiol
… main cell population infected by HTLV-1. Further, we report the infection of neurons with
STLV-1 in spinal cord regions as well as in brain cortical and cerebellar sections of postmortem …

Immunohistochemical identification of HTLV‐III antigen in brains of patients with AIDS

DH Gabuzda, DD Ho, SM de la Monte… - Annals of Neurology …, 1986 - Wiley Online Library
… in Table 1. HTLV-I11 antigen was detected in situ in the … The cell contours were smooth,
without neuronal or glial pro… macrophages in the brains of macaque monkeys with STLV-I11 …

HTLV-1 associated neurological disorders

M Yasir Khan, I Nasib Khan, M Farman… - Current topics in …, 2017 - ingentaconnect.com
… -1 infected lymphocytes interaction with ECs of brain reveal … pect motor neuron disease.
The increase in titer of antiHTLV-… Highly active antiretroviral treatment against STLV-1 infection …

Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors

PV Afonso, M Mekaouche, F Mortreux… - Blood, The Journal …, 2010 - ashpublications.org
… -1–infected lymphocyte will cross the blood-brain barrier. Therefore, preventing the PVL
increase at the initiation of treatment should be beneficial in the long-term. This trial suggested …

Cellular factors involved in HTLV-1 entry and pathogenicit

H Hoshino - Frontiers in microbiology, 2012 - frontiersin.org
… T-lymphotrophic virus type 1 (STLV-1) and bovine leukemia virus (… In the brains of some
HAM/TSP patients, astrocytes are … to be necessary for neuronal growth and development. NRP-…

Neurological disorders associated with HTLV-1

DE McFarlin, H Koprowski - Retrovirus Infections of the Nervous System …, 1990 - Springer
… The second group had a spastic presentation with upper motor neuron abnormalities. A …
Tropical spastic paraplegia is primarily manifested by upper motor neuron dysfunction which …

Neurologic disease due to HTLV-1 infection

RR McKendall - Handbook of clinical neurology, 2014 - Elsevier
1 proviral DNA sequences have been compared to simian T-cell leukemia/lymphoma (STLV
In co-cultures of HTLV-1-infected lymphocytes with a human brain endothelial cell line that …

Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain

LR Sharer, LG Eptein, ES Cho, VV Joshi… - Human pathology, 1986 - Elsevier
Brain tissue from cases 1, 3, and 4 (see table 1) was fixed in … phages in STLV-III-infected
rhesus monkey brains contain … to gray matter disease, since neuronal loss was not a feature in …

HTLV-1 tropism and envelope receptor

N Manel, JL Battini, N Taylor, M Sitbon - Oncogene, 2005 - nature.com
… -1 was detected in a large spectrum of hematopoietic cell types and nonhematopoietic tissues,
including brain, … The human HTLV and simian STLV retroviruses are deltaretroviruses that …

Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS

S Gartner, P Markovits, DM Markovitz, RF Betts… - Jama, 1986 - jamanetwork.com
… we cultured brain specimens taken from patients with AIDS and neuro¬ … It is possible
that there is a cell(s) type present in human brain tissue other than an MM-like cell that is (1) …