Morphine for chronic neuropathic pain in adults

TE Cooper, J Chen, PJ Wiffen, S Derry… - Cochrane database …, 2017 - cochranelibrary.com
… of the likely effect, and the likelihood that the effect will be … results of treatment compared to
the effects found in larger, better … if morphine is useful for the treatment of neuropathic pain. …

Morphine, gabapentin, or their combination for neuropathic pain

I Gilron, JM Bailey, D Tu, RR Holden… - … England Journal of …, 2005 - Mass Medical Soc
… of neuropathic pain with the combination of gabapentin and morphine results in less pain
of a combination of gabapentin and morphine in the treatment of neuropathic pain. Given the …

Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions

DJ Mayer, J Mao, J Holt… - Proceedings of the …, 1999 - National Acad Sciences
… We have recently shown in a rat model of neuropathic pain … of tolerance to the analgesic
effects of morphine. Of particular … associated with both CCI and morphine tolerance. A site of …

Opioids in neuropathic pain

R Przewlocki, B Przewlocka - Current pharmaceutical design, 2005 - ingentaconnect.com
… for the lower efficacy of morphine in neuropathic pain. In fact, the attenuated antiallodynic
effect of morphine in an animal model of neuropathic pain (chronic constriction injury of the …

… reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain

J Mao, DD Price, DJ Mayer - Pain, 1995 - Elsevier
… opiate effects or lack of effects on neuropathic pain states (… to opiate treatment in neuropathic
pain patients may result from … the development of neuropathic pain syndromes and also …

Changes in morphine reward in a model of neuropathic pain

CM Cahill, L Xue, P Grenier, C Magnussen… - Behavioural …, 2013 - journals.lww.com
morphine can elicit a rewarding effect in neuropathic pain, but the dose dependency of this
effect … or sham animals produced a CPP in chronic pain animals. In addition, preference for …

Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain

MH Rashid, M Inoue, K Toda, H Ueda - Journal of Pharmacology and …, 2004 - ASPET
… It is well known that the analgesic potency of morphine is reduced in neuropathic pain. In …
of systemic morphine in neuropathic pain might be caused by the loss of morphine analgesia at …

Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine

M Narita, A Nakamura, M Ozaki, S Imai… - …, 2008 - nature.com
… oxycodone may be a useful alternative to morphine in the treatment of neuropathic pain. …
the rewarding effects of sc-administered morphine or oxycodone under a neuropathic pain-like …

Offset analgesia in neuropathic pain patients and effect of treatment with morphine and ketamine

M Niesters, E Hoitsma, E Sarton, L Aarts… - The Journal of the …, 2011 - pubs.asahq.org
… in a population of patients with neuropathic pain (NP) with small-fiber neuropathy (SFN) and
… assessed the effect of analgesic treatment on OA in NP patients. The effect of morphine and …

Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain

S Hao, M Mata, W Goins, JC Glorioso, DJ Fink - Pain, 2003 - Elsevier
… We examined the effect of tolerance to morphine on the antiallodynic effect of transduction
with SHPE in neuropathic pain. Morphine tolerance was induced by injection of morphine (10 …