… for neuroprotection. Two major forms of CNS injury are traumatic brain injury (TBI) and spinal
cord injury (SCI… TBI is the term applied to brain injury caused by external physical trauma. A …

… Moreover, we assess data supporting use of neuroprotective drugs that are currently
being evaluated in human clinical trials for TBI, as well as promising emerging experimental …

… the innate immune response and improves histopathology after traumatic brain injury. …
neuroprotective intervention will be efficacious in patients with diverse types of brain injury. …

Traumatic brain injury (TBI) elicits an inflammatory response in the central nervous system (CNS)
that involves both resident and peripheral immune cells. Neuroinflammation can …

Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments that …

… 5 days given to patients within 8 h of moderate or severe traumatic brain injury were not
neuroprotective and might even have a negative effect in the treatment of significant head injury. …

… validated secondary injury mechanism in traumatic brain injury (TBI) as demonstrated by
the efficacy of various pharmacological antioxidants agents in decreasing post-traumatic free …

Significance: A vast amount of circumstantial evidence implicates high energy oxidants and
oxidative stress as mediators of secondary damage associated with traumatic brain injury. …

… or preventing the secondary injury. Currently, there is no neuroprotective agent demonstrated
in a large… of TBI, discuss trials investigating neuroprotective therapies in TBI that have been …

… concepts of traumatic brain injury, as well as an outlook on possible future developments
in … neuroprotection. Modern medical treatment modalities of traumatic brain injury (TBI), …