… only be a brain disorder but also a systemic disease, developing a specific treatment strategy
from a systemic viewpoint may provide a novel approach to AD prevention and treatment. …

… system drug development, the Institute of Medicine’s Forum on Neuroscience and Nervous
System Disorders … and offer potential strategies to improve the translational neuroscience. …

… close phylogenetic relationship to humans and similar developmental paths in (neuro)anatomy,
physiology, … , diagnosis and drug discovery, and touches upon ethical and legal aspects. …

… Abstract: Alzheimer’s disease (AD) clinical drug development and patient care depend on
rating instruments, research designs and methods, and translations of clinical trial (CT) results …

… of clinical symptoms [4] have changed our focus from treatment to prevention of this disease.
This new concept of preclinical AD implies a new definition of prevention levels; thus it …

Drug development guidelines from regulatory authorities provide important information to …
needed to support approval of new drugs. In the field of Alzheimer’s disease (AD), recently …

… DR and hybrid drug design with the goal of unravelling new drugs and targets to tackle AD.
… drug design strategy that simultaneously modifies multiple targets in the treatment of AD has …

… for the AD field with regard to future drug development and prevention. Brain PET imaging
… Applied machine learning in Alzheimer's disease research: omics, imaging, and clinical data…

… Failure to advance neuroscience knowledge by using … of disease and treatment Commitment
of clinical neuroscience to … , modern drug development, as seen in Alzheimer's disease, has …

… novel insights will provide a basis for further drug development for this terrible disease. …
recent developments in preclinical research that are promising with regard to drug development. …