Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice

X Wu, C Liu, L Chen, YF Du, M Hu, MN Reed… - International …, 2019 - Elsevier
… indicated that TUDCA can improve cognitive impairment and neurotoxicity induced by LPS in
mice, which … effects of TUDCA on cognitive impairment and neurotoxicity induced by LPS in …

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice

RM Ramalho, AF Nunes, RB Dias, JD Amaral… - Neurobiology of …, 2013 - Elsevier
… To investigate whether TUDCA prevents this potentially neurotoxic inflammatory response
in vitro, we evaluated the presence and reactivity of astrocytes. The proportion of neurons/…

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

M Castro-Caldas, AN Carvalho, E Rodrigues… - Molecular …, 2012 - Springer
mice to investigate the neuroprotective role of TUDCA against MPTP toxicity. Interestingly,
we show that pre-treatment of mice with TUDCA … role of TUDCA against MPTP neurotoxicity, …

Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases

K Khalaf, P Tornese, A Cocco, A Albanese - Translational …, 2022 - Springer
mice with TUDCA treatment. Moreover, locomotor and sensorimotor deficits were significantly
improved in the TUDCA-treated mice [25]… in animals by administering neurotoxic drugs, by …

Tauroursodeoxycholic acid improves motor symptoms in a mouse model of Parkinson's disease

AI Rosa, S Duarte-Silva, A Silva-Fernandes… - Molecular …, 2018 - Springer
… On the other hand, although mice treated with TUDCA after MPTP administration showed …
no longer detected at 45 days post the neurotoxic insult. Importantly, hindlimb clasping was …

Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson's disease

E Cuevas, S Burks, J Raymick, B Robinson… - Nutritional …, 2022 - Taylor & Francis
… alone does not produce any significant neurotoxic effects [Citation28]. However, when
administered with MPTP, PROB exacerbates the neurotoxicity and causes severe dopaminergic …

Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response

Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
… -tetrahydropyridine (MPTP), TUDCA has been shown to ameliorate the … TUDCA treatment
improved cognitive impairment and neurotoxicity induced by lipopolysaccharide (LPS) in mice

TGFβ contributes to the anti-inflammatory effects of tauroursodeoxycholic acid on an animal model of acute neuroinflammation

N Yanguas-Casás, MA Barreda-Manso… - Molecular …, 2017 - Springer
… Moreover, we found a significant increase in TGFβ3 staining in mice treated with both
LPS and TUDCA compared to mice treated with LPS alone in the temporal cortex (p < 0.05), …

Tauroursodeoxycholic acid prevents E22Q Alzheimer's Aβ toxicity in human cerebral endothelial cells

RJS Viana, AF Nunes, RE Castro, RM Ramalho… - Cellular and molecular …, 2009 - Springer
… Based on our previous findings demonstrating an inhibitory role of TUDCA on Aβ neurotoxicity,
we … is neuroprotective in pharmacological and transgenic mouse models of Huntington s …

Tauroursodeoxycholic acid ameliorates lipopolysaccharide-induced depression like behavior in mice via the inhibition of neuroinflammation and oxido-nitrosative …

L Cheng, C Huang, Z Chen - Pharmacology, 2019 - karger.com
Tauroursodeoxycholic acid (TUDCA), a clinically … of TUDCA on lipopolysaccharide (LPS)-induced
depression-like behavior, neuroinflammation, and oxido-nitrosative stress in mice. …