Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice
… indicated that TUDCA can improve cognitive impairment and neurotoxicity induced by LPS in
mice, which … effects of TUDCA on cognitive impairment and neurotoxicity induced by LPS in …
mice, which … effects of TUDCA on cognitive impairment and neurotoxicity induced by LPS in …
Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice
RM Ramalho, AF Nunes, RB Dias, JD Amaral… - Neurobiology of …, 2013 - Elsevier
… To investigate whether TUDCA prevents this potentially neurotoxic inflammatory response
in vitro, we evaluated the presence and reactivity of astrocytes. The proportion of neurons/…
in vitro, we evaluated the presence and reactivity of astrocytes. The proportion of neurons/…
Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease
M Castro-Caldas, AN Carvalho, E Rodrigues… - Molecular …, 2012 - Springer
… mice to investigate the neuroprotective role of TUDCA against MPTP toxicity. Interestingly,
we show that pre-treatment of mice with TUDCA … role of TUDCA against MPTP neurotoxicity, …
we show that pre-treatment of mice with TUDCA … role of TUDCA against MPTP neurotoxicity, …
Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases
K Khalaf, P Tornese, A Cocco, A Albanese - Translational …, 2022 - Springer
… mice with TUDCA treatment. Moreover, locomotor and sensorimotor deficits were significantly
improved in the TUDCA-treated mice [25]… in animals by administering neurotoxic drugs, by …
improved in the TUDCA-treated mice [25]… in animals by administering neurotoxic drugs, by …
Tauroursodeoxycholic acid improves motor symptoms in a mouse model of Parkinson's disease
AI Rosa, S Duarte-Silva, A Silva-Fernandes… - Molecular …, 2018 - Springer
… On the other hand, although mice treated with TUDCA after MPTP administration showed …
no longer detected at 45 days post the neurotoxic insult. Importantly, hindlimb clasping was …
no longer detected at 45 days post the neurotoxic insult. Importantly, hindlimb clasping was …
Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson's disease
E Cuevas, S Burks, J Raymick, B Robinson… - Nutritional …, 2022 - Taylor & Francis
… alone does not produce any significant neurotoxic effects [Citation28]. However, when
administered with MPTP, PROB exacerbates the neurotoxicity and causes severe dopaminergic …
administered with MPTP, PROB exacerbates the neurotoxicity and causes severe dopaminergic …
Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response
Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
… -tetrahydropyridine (MPTP), TUDCA has been shown to ameliorate the … TUDCA treatment
improved cognitive impairment and neurotoxicity induced by lipopolysaccharide (LPS) in mice …
improved cognitive impairment and neurotoxicity induced by lipopolysaccharide (LPS) in mice …
TGFβ contributes to the anti-inflammatory effects of tauroursodeoxycholic acid on an animal model of acute neuroinflammation
N Yanguas-Casás, MA Barreda-Manso… - Molecular …, 2017 - Springer
… Moreover, we found a significant increase in TGFβ3 staining in mice treated with both
LPS and TUDCA compared to mice treated with LPS alone in the temporal cortex (p < 0.05), …
LPS and TUDCA compared to mice treated with LPS alone in the temporal cortex (p < 0.05), …
Tauroursodeoxycholic acid prevents E22Q Alzheimer's Aβ toxicity in human cerebral endothelial cells
RJS Viana, AF Nunes, RE Castro, RM Ramalho… - Cellular and molecular …, 2009 - Springer
… Based on our previous findings demonstrating an inhibitory role of TUDCA on Aβ neurotoxicity,
we … is neuroprotective in pharmacological and transgenic mouse models of Huntington s …
we … is neuroprotective in pharmacological and transgenic mouse models of Huntington s …
Tauroursodeoxycholic acid ameliorates lipopolysaccharide-induced depression like behavior in mice via the inhibition of neuroinflammation and oxido-nitrosative …
L Cheng, C Huang, Z Chen - Pharmacology, 2019 - karger.com
… Tauroursodeoxycholic acid (TUDCA), a clinically … of TUDCA on lipopolysaccharide (LPS)-induced
depression-like behavior, neuroinflammation, and oxido-nitrosative stress in mice. …
depression-like behavior, neuroinflammation, and oxido-nitrosative stress in mice. …
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