… β-lactams penicillin, cephalosporins, monobactams and carbapenems have a β-lactam ring
which can be hydrolysed by βlactamases … a multitude of β-lactams has led to overproduction …

… β-lactamases. Some of the most problematic enzymes in the clinical community include
extended-spectrum β-lactamases (… addressed with new β-lactamase inhibitor combinations. New …

… β-lactamases in the same organism. In this Review, descriptions are provided for medically
relevant β-lactamase … readily inhibited by tazobactam and by newer BLIs, such as avibactam, …

… to produce a 13-lactamase responsible for resistance to newer 13-lactam antibiotics. The
test … or decreased susceptibility to newer 13-lactam agents (class I /3-lactamase-overproducing …

… (often referred to as plasmid-mediated AmpC β-lactamases) are an increasing cause of
clinical concern. These “newer β-lactamases” cause resistance to a wide range of β-lactam …

… , and carbapenem-hydrolyzing β-lactamases at least a decade ago, … newer β-lactamases.
Therefore, a study was conducted in 2000 to investigate the occurrence of these β-lactamases …

… -resistant variants of common β-lactamases. This article addresses the role of the clinical
microbiology laboratory in detecting and reporting the newer β-lactamases. It also covers other …

… A number of β-lactam antibiotics that are relatively resistant to hydrolysis by β-lactamases …
of microbial cross-resistance to multiple β-lactam antibiotics and occasionally to the …

… β-lactamases now described, it is a struggle to keep abreast of the various types of β-lactamases, …
Part II of this article will provide a discussion of AmpC β-lactamases and other β-lactam …

… β-lactam antibiotics is a major problem in patients infected with organisms that characteristically
produce inducible β-lactamases-… with one of the newer cephalosporins. The emergence …