[HTML][HTML] Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways

H Gao, Y Sun, Y Wu, B Luan, Y Wang, B Qu, G Pei - Molecular cell, 2004 - cell.com
… Here we show that β-arrestin2 directly interacts with IκBα (inhibitor of NF-κB, the key … , β-arrestin2
effectively modulates activation of NF-κB and expression of NF-κB target genes…

β-Arrestin 2 is required for lysophosphatidic acid-induced NF-κB activation

J Sun, X Lin - Proceedings of the National Academy of …, 2008 - National Acad Sciences
… in NF-κB activation induced by other signaling pathways (20–23). Our results suggest that
β-arrestin 2 mediates NF-κB … Together, our studies reveal a function of β-arrestin 2 in GPCR-…

Arresting NF-jB by b-arrestin2

F Chen - Cell death and differentiation, 2004 - nature.com
… Therefore, the likely mechanism for β-arrestin2 regulation of NF-κBNF-κB heterodimer
in either cytosol or nuclei as proposed by the authors. The second question is whether β-arrestin2

[HTML][HTML] βarrestin2 promotes 5‑FU‑induced apoptosis via the NFκB pathway in colorectal cancer

W Ren, T Wang, X He, Q Zhang, J Zhou… - Oncology …, 2018 - spandidos-publications.com
… It has been proved that the NF-κB … , β-arrestin2 is a negative element for the NF-κB activity.
Therefore, we questioned whether the effect of β-arrestin2 on apoptosis depends on NF-κB

βArrestin2 functions as a phosphorylation‐regulated suppressor of UV‐induced NFκB activation

B Luan, Z Zhang, Y Wu, J Kang, G Pei - The EMBO journal, 2005 - embopress.org
… We then compared the effect of βarrestin2 and the 4M mutant on NFκB signaling pathway
… whether βarrestin2 suppression of NFκB activation induced by UV was stimulated by β 2 …

β-arrestin2 regulates the anti-inflammatory effects of Salmeterol in lipopolysaccharide-stimulated BV2 cells

M Sharma, PM Flood - Journal of neuroimmunology, 2018 - Elsevier
… the expression of β-arrestin2 and enhances the interaction between β-arrestin2 and TAB1
(TAK1-binding protein), reduced TAK1/TAB1 mediated activation of NFκB and expression of …

The role and mechanism of β-arrestin2 in signal transduction

TL Ma, Y Zhou, CY Zhang, ZA Gao, JX Duan - Life Sciences, 2021 - Elsevier
… of β-arrestin2, the regulation of β-arrestin2 based signaling pathways. The role and mechanism
of β-arrestin2 … The prospect of regulating the expression and activity of β-arrestin2 in …

β-Arrestin 2 mediates G protein-coupled receptor 43 signals to nuclear factor-κB

SU Lee, HJ In, MS Kwon, B Park, M Jo… - Biological and …, 2013 - jstage.jst.go.jp
… Here, we show that β-arrestin 2 mediates the internalization of GPR43 by agonist. Agonism
… factor-κB (NF-κB), which was relieved by short interfering RNA (siRNA) of β-arrestin 2. …

β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα

DS Witherow, TR Garrison, WE Miller… - Proceedings of the …, 2004 - National Acad Sciences
… Overexpression of either β-arrestin 1 or β-arrestin 2 led to marked inhibition of NF-κB activity,
… Inhibition of NF-κB activity was independent of the type of stimulus used for NF-κB activation…

[HTML][HTML] β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice

MP Jiang, C Xu, YW Guo, QJ Luo, L Li… - World Journal of …, 2018 - ncbi.nlm.nih.gov
… Our results showed that ALT and AST levels and histopathology scores were higher in β-arrestin
2 KO mice than in β-arrestin 2 WT mice, which suggested that decreased β-arrestin 2