Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

Y Tian, J Ma, W Wang, L Zhang, J Xu, K Wang… - Molecular and cellular …, 2016 - Springer
AMPKα-SIRT1 pathway and then decrease the NF-κB inflammation pathway. To confirm our
hypothesis, AMPKα and SIRT1 … As expected, inhibition of AMPKα and SIRT1 could further …

Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway

S Wang, W Wang, H Sheng, Y Bai, Y Weng… - International …, 2020 - Elsevier
SIRT1 is indispensable to the reduction of NF-κB transcriptional activity by hesperetin, we
inhibited SIRT1 via … NF-κB binding motifs. As shown in Fig. 3A, hesperetin did not suppressed …

Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway

F Li, Y Chen, Y Li, M Huang, W Zhao - European Journal of Pharmacology, 2020 - Elsevier
… In order to further detect whether GE affected AMPK/SIRT1/NF-κB pathway in the kidney,
we tested the relative protein levels of p–NFκB, ASC, Cleave-IL-1β, NLRP3, Cleave-Caspase-…

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

A Kauppinen, T Suuronen, J Ojala, K Kaarniranta… - Cellular signalling, 2013 - Elsevier
… The inhibition of SIRT1 disrupts oxidative energy metabolism and stimulates the NF-κB-… of
the antagonistic signaling between NF-κB and SIRT1 and describe how this crosstalk controls …

Apoptotic extracellular vesicles alleviate Pg‐LPS induced inflammatory responses of macrophages via AMPK/SIRT1/NFκB pathway and inhibit osteoclast formation

Q Ye, H Xu, S Liu, Z Li, J Zhou, F Ding… - Journal of …, 2022 - Wiley Online Library
… of NF-κB after ApoEVs treatment. Adenosine monophosphate-activated protein kinase (AMPK),
HIF-1α, AKT, and SIRT1 are potential regulators of NF-κB … of HIF-1α, and SIRT1 while …

Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

Z Zheng, Y Bian, Y Zhang, G Ren, G Li - Cell Cycle, 2020 - Taylor & Francis
… /SIRT1/NF-κB signaling to … /SIRT1 pathway to cause pyroptotic death upon metformin
treatment. This research firstly reveals that metformin as a sensitizer amplifies AMPK/SIRT1/NF-κB

Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice

HW Liu, SJ Chang - Frontiers in physiology, 2018 - frontiersin.org
… Exercise training increased SIRT1 and PGC1α expression and AMPKα and mitochondrial
… moderate exercise training inhibits NFκB signaling and activates SIRT1-AMPKα-PGC1α axis…

Quercetin modulates AMPK/SIRT1/NFκB signaling to inhibit inflammatory/oxidative stress responses in diabetic high fat diet‑induced atherosclerosis in the rat carotid …

F Zhang, J Feng, J Zhang… - Experimental and …, 2020 - spandidos-publications.com
… Upregulation of SIRT1 expression or increased SIRT1 … the expression of SIRT1 and repress
the expression of NF-κB, IL-… of the AMPK/SIRT1/NF-κB signaling pathway by quercetin was …

The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 …

H Song, Z Ding, J Chen, T Chen, T Wang… - Immunopharmacology …, 2022 - Taylor & Francis
SIRT1 was attenuated and phosphorylation of FoxO1-NF-κB … activated the AMPK-SIRT1-FoxO1-NF-κB
pathway. These … by activating the SIRT1 AMPK-SIRT1-FoxO1-NF-κB pathway-…

Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway

B Xue, Z Yang, X Wang, H Shi - 2012 - journals.plos.org
… of AMPK/SIRT1 activation by ω-3 PUFAs, we examined the NF-κB acetylation and signaling…
SIRT1 to deacetylate NF-κB, and SIRT1 mediates the effect of DHA in deacetylation of NF-κB