… Disease (AD) Rheumatoid Arthritis (RA), which exhibits high levels of inflammatory cytokines
such as IL-1, TNFa and IL-6 linked to bone erosion and disease progression. NF-kB is also …

… PQQ prevented arthritis progression and synovium inflammation in CIA mice. Macroscopic
evidences of arthritis (such as erythema or swelling) in different groups of mice were …

… Animal models of inflammatory arthritis also support the concept that NF-κB plays a very
active role in the development and progression of arthritis in vivo37, 38. NF-κB activation prior to …

… RA progression. The potential mechanism might be based on the attenuation TLR4-NF-κB …
for alleviating RA progress through inhibiting inflammations and NF-κB signalling pathway. …

Background: Rheumatoid arthritis (RA) is a chronic articular synovial inflammatory disease.
The precise etiology underlying the pathogenesis of RA remains unknown. We aimed to …

… OA) onset and progression. Therefore, targeted strategies that interfere with NF-κB signalling
… Osteoarthritis (OA) is a common arthritic disease which gradually leads to cellular changes, …

… pathogenesis of rheumatoid arthritis. Here we attempt to slow arthritis progression by co-delivering
the glucocorticoid dexamethasone (Dex) and small-interfering RNA targeting NF-kB …

… than that in the rheumatoid arthritis (RA) synovium [34]. Because NF-κB acts as a general
and … IL-1β-induced NF-κB activation or experimental OA progression. Studies of SERPINE2, …

… of RGS10 as a negative regulator of RA progression via modulation of the NF-κB pathway.
Under physiological conditions, the transcription factor NF-κB is entrapped in the cytoplasm in …

… factor NF-κB has been well recognized as a pivotal regulator of inflammation in rheumatoid
arthritis (RA), but recent developments revealed a broad involvement of NF-κB in other …