… Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

… process and dysfunction in redox cell signaling has been associated with the pathogenesis
… by enzymatic or oxidative processes. The enzymes included in these processes are NOS, …

… processes may be part of a single causal chain resulting in cell death: the cytokines induce
nitric oxide … pathways in neurodegeneration in the so-called neurodegenerative dementias. …

… in the Central Nervous System (CNS), nitric oxide (NO) can have both, neuroprotective or …
in many of the processes leading to neurodegeneration in several neurological disorders …

… in neurodegenerative processes can provide essential elements to understanding the
mechanisms of these diseases. The cyclic GMP (cGMP) pathway’s activation, for example, is an …

… Nitric oxide acts as a messenger, activating soluble guanylyl cyclase and participating …
Nitric oxide also binds to cytochrome c oxidase, and is able to inhibit cell respiration in a process …

… function, consider potential mechanisms of mitochondrial damage, and evaluate the relevance
of such processes for our understanding of the etiology of neurodegenerative disorders. …

… the neurodegenerative process. Much of the oxidative damage of proteins is brought about
by the overproduction of nitric oxide by nitric oxide … , the level of nitric oxide is subject to tight …

… of a variety of physiologic processes; however, under … process will hopefully lead to the
development of selective therapeutic agents and to a better understanding of basic processes …

… In summary, excessive production and accumulation of nitric oxide is deleterious to
neurons in the inflammation-mediated neurodegenerative process. Agents that are capable of …