Role of nitric oxide in Parkinson's disease

L Zhang, VL Dawson, TM Dawson - Pharmacology & therapeutics, 2006 - Elsevier
… studies on S-nitrosylation in Parkinson's disease and other neurodegenerative diseases
will shed light on our understanding of pathogenic mechanisms underlying these diseases. …

Nitric oxide and reactive oxygen species in Parkinson's disease

K Tieu, H Ischiropoulos, S Przedborski - IUBMB life, 2003 - Wiley Online Library
… of these isoforms is responsible for the production of nitric oxide in the pathogenesis of PD.
The … produced nitric oxide contributes in part to the MPTP neurotoxicity and that nitric oxide

Nitric oxide synthase regulation and diversity: implications in Parkinson's disease

R Kavya, R Saluja, S Singh, M Dikshit - Nitric Oxide, 2006 - Elsevier
Nitric oxide (NO) is a unique chemical messenger that has … Nitric oxide synthase (NOS), the
key enzyme in the biosynthesis … implicated in the pathogenesis of Parkinson’s disease (PD), …

Nitric oxide synthase and neuronal vulnerability in Parkinson's disease

S Hunot, F Boissiere, B Faucheux, B Brugg… - Neuroscience, 1996 - Elsevier
… in the mesencephalon of four patients with idiopathic Parkinson's disease and three …
inducible isoform of nitric oxide synthase (the enzyme involved in the synthesis of nitric oxide), we …

Apoptotic neuronal death in Parkinson's disease: involvement of nitric oxide

S Singh, M Dikshit - Brain research reviews, 2007 - Elsevier
… in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Both extrinsic and
Nitric oxide (NO) seems to be a central molecule due to its ability to modulate both pro and …

Role of nitric oxide in motor control: implications for Parkinson's disease pathophysiology and treatment

E Del-Bel, F Eduardo Padovan-Neto… - Current …, 2011 - ingentaconnect.com
… of nitric oxide on motor control and in Parkinson’s disease, particularly a possible role of
nitric oxide in … Recent results show that nitric oxide synthase inhibition reduces L-DOPA-induced …

Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols

K Aquilano, S Baldelli, G Rotilio, MR Ciriolo - Neurochemical research, 2008 - Springer
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by several … PD
might result also from the actions of altered production of nitric oxide (NO). Indeed, high levels of …

Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis

MF Beal - Annals of neurology, 1998 - Wiley Online Library
… Increases in cellular calcium are also as sociated with activation of nitric oxide synthase (NOS).
The increases in generation of Superoxide and nitric oxide (NO) can lead to the …

An update on the role of nitric oxide in the neurodegenerative processes of Parkinson's disease

F Javier Jimenez-Jimenez… - Current medicinal …, 2016 - ingentaconnect.com
… in Parkinson's disease enhance nitric oxide release of normal human neutrophils. J. Neurol.
… Significantly reduced salivary nitric oxide synthesis in patients with Parkinson's disease. …

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

GT Liberatore, V Jackson-Lewis, S Vukosavic… - Nature medicine, 1999 - nature.com
… neurons as seen in Parkinson disease. Here we show that after … significant upregulation of
inducible nitric oxide synthase (iNOS)… protective benefit in the treatment of Parkinson disease. …