Nitric oxide synthase inhibition and cerebrovascular regulation

C Iadecola, DA Pelligrino… - Journal of Cerebral …, 1994 - journals.sagepub.com
There is increasing evidence that nitric oxide (NO) is an important molecular messenger
involved in a wide variety of biological processes. Recent data suggest that NO is also involved …

Inducible nitric oxide synthase inhibitors: A comprehensive update

R Minhas, Y Bansal, G Bansal - Medicinal Research Reviews, 2020 - Wiley Online Library
Nitric oxide (NO) is a relaxing factor derived from endothelium, which is responsible for … is
effected by nitric oxide synthase (NOS) through catalysis of NADPH-dependent oxidation of l-…

Nitric oxide synthases: structure, function and inhibition

WK Alderton, CE Cooper, RG Knowles - Biochemical journal, 2001 - portlandpress.com
… on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the …
), biopterin, arginine, and the many inhibitors which interact with them. The exact nature of the …

Nitric oxide synthase inhibitors

DB Vaupel, AS Kimes, ED London - Neuropsychopharmacology, 1995 - nature.com
… Four inhibitors of nitric oxide synthase (NOS), administered as acute pretreatments,
attenuated several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats. …

Nitric oxide synthase inhibition in migraine

LH Lassen, M Ashina, I Christiansen, V Ulrich, J Olesen - The Lancet, 1997 - thelancet.com
… This was explored by studying the effect of the nitric oxide synthase (NOS) inhibitor LN G …
is most likely to be a specific result of NOS inhibition. Thus, NO seems to be involved not only in …

Approaches toward selective inhibition of nitric oxide synthase

MA Marletta - Journal of medicinal chemistry, 1994 - ACS Publications
… on enzymatic reaction mechanisms, particularly those of nitric oxide synthase and guanylate
cyclase. The intense interest and rapid pace of nitric oxide (’NO) research has occurred, at …

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?

L Rochette, J Lorin, M Zeller, JC Guilland… - Pharmacology & …, 2013 - Elsevier
nitric oxide free radical ( radical dot NO) metabolism and disease. NO is synthetized enzymatically
from l-Arg by NO synthases. … The synthesis of NO is selectively inhibited by guanidino-…

Feedback inhibition of nitric oxide synthase activity by nitric oxide.

J Assreuy, FQ Cunha, FY Liew… - British journal of …, 1993 - ncbi.nlm.nih.gov
… NO inhibits NO synthase irreversibly. Keywords: Nitric oxide; nitric oxide synthase inhibition;
macrophage; J774 cells … Nitric oxide synthase activity was determined 12 h after stimulation. …

Kynurenamines as neural nitric oxide synthase inhibitors

A Entrena, ME Camacho, MD Carrión… - Journal of medicinal …, 2005 - ACS Publications
To find new compounds with potential neuroprotective activity, we have designed,
synthesized, and characterized a series of neural nitric oxide synthase (nNOS) inhibitors with a …

Inhibition of nitric oxide synthase as a potential therapeutic target

AJ Hobbs, A Higgs, S Moncada - Annual review of …, 1999 - annualreviews.org
… LJ, 1994; Nitric oxide inhibits neuronal nitric oxide synthase byinteracting with the heme
prosthetic group. Role of tetrahydrobiopterin inmodulating the inhibitory action of nitric oxide. …