Nitric oxide synthase inhibition and cerebrovascular regulation
C Iadecola, DA Pelligrino… - Journal of Cerebral …, 1994 - journals.sagepub.com
There is increasing evidence that nitric oxide (NO) is an important molecular messenger
involved in a wide variety of biological processes. Recent data suggest that NO is also involved …
involved in a wide variety of biological processes. Recent data suggest that NO is also involved …
Inducible nitric oxide synthase inhibitors: A comprehensive update
… Nitric oxide (NO) is a relaxing factor derived from endothelium, which is responsible for … is
effected by nitric oxide synthase (NOS) through catalysis of NADPH-dependent oxidation of l-…
effected by nitric oxide synthase (NOS) through catalysis of NADPH-dependent oxidation of l-…
Nitric oxide synthases: structure, function and inhibition
WK Alderton, CE Cooper, RG Knowles - Biochemical journal, 2001 - portlandpress.com
… on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the …
), biopterin, arginine, and the many inhibitors which interact with them. The exact nature of the …
), biopterin, arginine, and the many inhibitors which interact with them. The exact nature of the …
Nitric oxide synthase inhibitors
DB Vaupel, AS Kimes, ED London - Neuropsychopharmacology, 1995 - nature.com
… Four inhibitors of nitric oxide synthase (NOS), administered as acute pretreatments,
attenuated several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats. …
attenuated several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats. …
Nitric oxide synthase inhibition in migraine
… This was explored by studying the effect of the nitric oxide synthase (NOS) inhibitor LN G …
is most likely to be a specific result of NOS inhibition. Thus, NO seems to be involved not only in …
is most likely to be a specific result of NOS inhibition. Thus, NO seems to be involved not only in …
Approaches toward selective inhibition of nitric oxide synthase
MA Marletta - Journal of medicinal chemistry, 1994 - ACS Publications
… on enzymatic reaction mechanisms, particularly those of nitric oxide synthase and guanylate
cyclase. The intense interest and rapid pace of nitric oxide (’NO) research has occurred, at …
cyclase. The intense interest and rapid pace of nitric oxide (’NO) research has occurred, at …
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?
L Rochette, J Lorin, M Zeller, JC Guilland… - Pharmacology & …, 2013 - Elsevier
… nitric oxide free radical ( radical dot NO) metabolism and disease. NO is synthetized enzymatically
from l-Arg by NO synthases. … The synthesis of NO is selectively inhibited by guanidino-…
from l-Arg by NO synthases. … The synthesis of NO is selectively inhibited by guanidino-…
Feedback inhibition of nitric oxide synthase activity by nitric oxide.
… NO inhibits NO synthase irreversibly. Keywords: Nitric oxide; nitric oxide synthase inhibition;
macrophage; J774 cells … Nitric oxide synthase activity was determined 12 h after stimulation. …
macrophage; J774 cells … Nitric oxide synthase activity was determined 12 h after stimulation. …
Kynurenamines as neural nitric oxide synthase inhibitors
A Entrena, ME Camacho, MD Carrión… - Journal of medicinal …, 2005 - ACS Publications
To find new compounds with potential neuroprotective activity, we have designed,
synthesized, and characterized a series of neural nitric oxide synthase (nNOS) inhibitors with a …
synthesized, and characterized a series of neural nitric oxide synthase (nNOS) inhibitors with a …
Inhibition of nitric oxide synthase as a potential therapeutic target
AJ Hobbs, A Higgs, S Moncada - Annual review of …, 1999 - annualreviews.org
… LJ, 1994; Nitric oxide inhibits neuronal nitric oxide synthase byinteracting with the heme
prosthetic group. Role of tetrahydrobiopterin inmodulating the inhibitory action of nitric oxide. …
prosthetic group. Role of tetrahydrobiopterin inmodulating the inhibitory action of nitric oxide. …
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