Crystal structure of the human NK1 tachykinin receptor

J Yin, K Chapman, LD Clark, Z Shao… - Proceedings of the …, 2018 - National Acad Sciences
… Antagonists of the human NK 1 tachykinin receptor are used to treat chemotherapy-induced …
1 receptor bound to a high-affinity antagonist. This structure of a tachykinin receptor reveals …

The dual nature of the tachykinin NK1 receptor

CA Maggi, TW Schwartz - Trends in pharmacological sciences, 1997 - cell.com
receptor. The consensus agreement on this point rapidly became a tenet in the tachykinin
receptor … -talk between different tachykinins at the different receptors, the NK 1 receptor was de …

Biological and pharmacological aspects of the NK1receptor

S Garcia-Recio, P Gascón - BioMed research international, 2015 - Wiley Online Library
Tachykinin receptors have been divided into three different types according to their affinity …
receptors per tachykinin is shown as follows [10, 11]. Order of affinity of tachykinin receptor by …

The tachykinin NK1 receptor in the brain: pharmacology and putative functions

A Saria - European journal of pharmacology, 1999 - Elsevier
tachykinins several classes of tachykinin receptors were discovered. … receptors
described so far are named tachykinin NK 1 receptor, tachykinin NK 2 receptor and tachykinin

Different Subtypes of Tachykinin NK1 Receptor Binding Sites Are Present in the Rat Brain

JC Beaujouan, M Saffroy, Y Torrens… - Journal of …, 2000 - Wiley Online Library
… activity on tachykinin NK 2 and NK 3 receptors and exhibits a low affinity for classic tachykinin
NK 1 … Filled and open circles correspond to tachykinin receptor antagonists and agonists, …

Immunolocalization of Full-length NK1 Tachykinin Receptors in Human Tumors

S Schulz, R Stumm, C Röcken… - … of Histochemistry & …, 2006 - journals.sagepub.com
… Given that the antibody raised and characterized here is directed to the end of the
cytoplasmic tail of the NK1-Fl receptor, it was not possible to detect NK 1 -Tr in the present study. …

Kinetic binding and activation profiles of endogenous tachykinins targeting the NK1 receptor

I Nederpelt, D Bleeker, B Tuijt, AP IJzerman… - Biochemical …, 2016 - Elsevier
… of endogenous tachykinins and derivatives thereof and their role in the activation of the NK1
receptor. We determined the binding kinetics of seven tachykinins targeting the NK1 receptor

The study of tachykinin receptors

E Burcher - Clinical and experimental pharmacology and …, 1989 - Wiley Online Library
tachykinin receptors in a number of peripheral tissues (Table 1). The gastrointestinal tract
usually contains both NK1 and … Distribution of characterized tachykinin receptors in peripheral …

NK1, NK2 and NK3 tachykinin receptor localization and tachykinin distribution in the ileum of the mouse

MG Vannucchi, MS Faussone-Pellegrini - Anatomy and embryology, 2000 - Springer
… three receptors immunohistochemically and the tachykinin (SP … into the target cells of
the tachykinincontaining neurons. For … -related differences in the tachykinin receptor localization. …

Role of tachykinin NK1, NK2 and NK3 receptors in the modulation of visceral hypersensitivity in the rat

GA Gaudreau, V Plourde - Neuroscience letters, 2003 - Elsevier
… the effect of spinal administration of tachykinin receptor antagonists in the mediation of … of
the NK 1 receptor antagonist RP-67,580 (6.5 nmol) and the NK 3 receptor antagonist R-820 (…