The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies

N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
NLRP3 inflammasome in COVID-19, this review describes the possible pathways of NLRP3
inflammasome activation … the NLRP3 inflammasome in the pathogenesis of COVID-19 and …

[HTML][HTML] Severe COVID-19: NLRP3 inflammasome dysregulated

DF Van den Berg, AA Te Velde - Frontiers in immunology, 2020 - frontiersin.org
… role of NLRP3 inflammasome activation in the severe symptomatic phase of COVID-19 and
… In search for a pathway to relate sustained NLRP3 inflammasome activation in aging we …

[HTML][HTML] Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
… -containing 3 (NLRP3) inflammasome pathway and … COVID-19 and NLRP3 activation
and describe an important role in targeting this pathway for the treatment of severe COVID-19

[HTML][HTML] Novel coronavirus-induced NLRP3 inflammasome activation: a potential drug target in the treatment of COVID-19

A Shah - Frontiers in immunology, 2020 - frontiersin.org
NLRP3 inflammasome appears to be a potential drug target in the treatment of coronavirus
disease 2019 (COVID-19… This manuscript highlights the importance of NLRP3 inflammasome

[HTML][HTML] The inflammasome in times of COVID-19

JC de Rivero Vaccari, WD Dietrich, RW Keane… - Frontiers in …, 2020 - frontiersin.org
COVID-19 patients. Here we review the literature regarding the mechanism of inflammasome
activation … , it seems that ORF3a promotes NLRP3 inflammasome activation by modulating …

Inflammasome activation in COVID-19 patients

TS Rodrigues, KSG de Sá, AY Ishimoto, A Becerra… - MedRxiv, 2020 - medrxiv.org
… has been highly speculated, the inflammasome activation and participation in the … NLRP3
inflammasome is activated in response to SARS-CoV-2 infection and it is active in COVID-19, …

[HTML][HTML] NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity

S Amin, S Aktar, MM Rahman, MMH Chowdhury - Microbes and infection, 2022 - Elsevier
… In this review, we focused on the occurrence of NLRP3 inflammasome activation in … interlink
between NLRP3 inflammasome activation and underlying conditions of COVID-19 severity, …

[HTML][HTML] Inflammasome activation at the crux of severe COVID-19

SM Vora, J Lieberman, H Wu - Nature Reviews Immunology, 2021 - nature.com
… cytosolic Ca 2+ influx to activate NLRP3 in reconstituted Vero epithelial cells 113,114 .
Another mechanism of NLRP3 inflammasome activation involves direct interactions with viral …

[HTML][HTML] Nutraceutical strategies for suppressing NLRP3 inflammasome activation: pertinence to the management of COVID-19 and beyond

MF McCarty, SB Iloki Assanga, L Lewis Luján… - Nutrients, 2020 - mdpi.com
… to inhibit NLRP3 inflammasome activation via interaction … useful in the cytokine storm phase
of COVID-19 [266,267,268]. … activation of NLRP3-dependent inflammasome activation by …

[HTML][HTML] Common NLRP3 inflammasome inhibitors and Covid-19: divide and conquer

GES Batiha, AI Al-Gareeb, D Rotimi, OS Adeyemi… - Scientific African, 2022 - Elsevier
… 2 may be linked to NLRP3 inflammasome activation which has … In SARS-CoV-2 infection,
NLRP3 inflammasome activation … selective inhibitors of NLRP3 inflammasome. To achieve this, …