… mechanisms of NLRP3 inflammasome activation to identify effective NLRP3 inhibitors (Table
2) … 2) and assess their therapeutic potential. Excitingly, a number of NLRP3 inhibitors have …

… Tau monomers and oligomers stimulated NLRP3 activation, but tau fibrils did not. In … by
activating NLRP3, indicating that the NLRP3 inflammasome may be a potential therapeutic target …

… NLRP3 inflammasome complex may serve as a promising and novel therapeutic target for
clinical treatment … of NLRP3 and its role in autoimmune diseases, as well as their potential as …

… As a member of the inflammasome family, the NLRP3 inflammasome … NLRP3 inflammasome
activation, its role in specific types of tumors and the novel therapeutic modalities targeting …

… by genetic ablation of NLRP3. Although these findings highlight the potential of NLRP3 as
a drug target, an understanding of NLRP3 structure and activation mechanisms is incomplete, …

… of NLRP3 inflammasome activation, how dysregulation of NLRP3 inflammasome activation
causes disease, and potential therapeutics that inhibit NLRP3 inflammasome activation. …

… therapeutic targets and innovative agents must be developed. Notably, the NLRP3 inflammasome
… assembly, the NLRP3 inflammasome is persistently activated during the pathogenesis …

… This study further showed that NLRP3 inflammasome activation is caused by the action of
cathepsin B released from the lysosome rather than the direct actions of Aβ. These findings …

… can block NLRP3 inflammasome activation in human patients [103].Despite the emerging
role of inflammasomes in immunity, no drug directly targeting the inflammasomes has been …

… Moreover, focusing on the NLRP3 inflammasome and combining with the upstream and …
of NLRP3 inflammasome as targets, we review the pharmacologically related targets and …