过去一年中添加的文章，按日期排序
Discovery and Development of NLRP3 Inhibitors Targeting the LRR Domain to Disrupt NLRP3-NEK7 Interaction for the Treatment of Rheumatoid Arthritis
B Li, P Li, L Wei, J Zou, Y Wang, Q You… - Journal of Medicinal …, 2024 - ACS Publications
7 天前 - … To find new therapeutic targets, … activation of the NLRP3 inflammasome can lead
to various inflammatory and autoimmune diseases, making it an ideal target for RA treatment. …
to various inflammatory and autoimmune diseases, making it an ideal target for RA treatment. …
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
E Hartenian, P Broz - Cell Research, 2024 - nature.com
7 天前 - … upon nigericin-induced activation of the NLRP3 inflammasome in human THP-1 …
Intriguingly, GSDMD deficiency reduced ROS production upon inflammasome activation…
Intriguingly, GSDMD deficiency reduced ROS production upon inflammasome activation…
Platelets in Kawasaki disease: mediators of vascular inflammation
M Noval Rivas, B Kocatürk, BS Franklin… - Nature Reviews …, 2024 - nature.com
8 天前 - … NLRP3 inflammasome activation and IL-1β production by human immune cells by
releasing soluble mediators. Activated … therapeutic targets for Kawasaki disease vasculitis. …
releasing soluble mediators. Activated … therapeutic targets for Kawasaki disease vasculitis. …
[HTML][HTML] Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury
S Gastaldi, M Giordano, F Blua, C Rubeo… - Vascular …, 2024 - Elsevier
8 天前 - … Several factors contribute to ischemia/reperfusion injury (IRI), including activation
of the NLRP3 inflammasome and its byproducts, such as interleukin-1β (IL-1β) and caspase-1…
of the NLRP3 inflammasome and its byproducts, such as interleukin-1β (IL-1β) and caspase-1…
Platelets in Kawasaki disease: mediators of vascular inflammation
MN Rivas, B Kocatürk, BS Franklin… - Nature reviews … - pubmed.ncbi.nlm.nih.gov
8 天前 - … NLRP3 inflammasome activation and IL-1β production by human immune cells by
releasing soluble mediators. Activated … vasculitis and therapeutic strategies targeting platelets …
releasing soluble mediators. Activated … vasculitis and therapeutic strategies targeting platelets …
Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models
HS Baek, VS Hong, H Kang, SJ Lee, JY Lee… - Inflammation …, 2024 - Springer
9 天前 - … THP-1 cells by inhibiting the activation of NLRP3 inflammasome. Notably, KMU-11342 …
the pathogenesis of RA and are considered potential therapeutic targets [26]. COXs are …
the pathogenesis of RA and are considered potential therapeutic targets [26]. COXs are …
WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury
Y Chen, T Long, J Chen, H Wei, J Meng… - International Journal of … - journals.lww.com
11 天前 - … The NLRP3 inflammasome, an important regulatory switch for … therapeutic target
for TBI.Our previous studies aimed to reveal the function of the NLRP3 inflammasome in TBI …
for TBI.Our previous studies aimed to reveal the function of the NLRP3 inflammasome in TBI …
2051-LB: Rhein Targets Macrophage SIRT2 to Promote Adipose Tissue Thermogenesis in Obesity
R ZHOU, Z ZHU, P XU, L SHEN, Z WANG, Y XUE… - Diabetes, 2024 - Am Diabetes Assoc
11 天前 - … inhibiting the activation of NLRP3 inflammasome in macrophages. Further study
proved that rhein directly interacts with SIRT2 and inhibits NLRP3 inflammasome activation in …
proved that rhein directly interacts with SIRT2 and inhibits NLRP3 inflammasome activation in …
G protein‐coupled estrogen receptor agonist G‐1 decreases ADAM10 levels and NLRP3‐inflammasome component activation in response to Staphylococcus aureus …
H Zheng, KD Triplett, ER Prossnitz, PR Hall… - …, 2024 - Wiley Online Library
12 天前 - … human immune cells in relation to the NLRP3 inflammasome. We used macrophage-like
… the importance of GPER in immune regulation and its potential as a therapeutic target. …
… the importance of GPER in immune regulation and its potential as a therapeutic target. …
Heparan sulfate acts as an activator of the NLRP3 inflammasome promoting inflammatory response in the development of acute pancreatitis
LJ Zhao, P Chen, L Huang, WQ He, YR Tang… - Journal of …, 2024 - Springer
13 天前 - … Despite the unequivocal involvement of NLRP3 inflammasome in the progression
of AP, the specific agonist responsible for NLRP3 inflammasome activation in this process …
of AP, the specific agonist responsible for NLRP3 inflammasome activation in this process …