… of activation of the NLRP3 inflammasome, its association with … the state of research into
NLRP3 inflammasome inhibitors. … go toward exploiting NLRP3 inflammasome inhibitors in our …

… roles in NLRP3 inflammasome activation. In this review, we summarize recent advances in
NLRP3 inflammasome activation and inhibitors that specifically and directly target NLRP3 to …

… to inhibit NLRP3 inflammasome. In the recent years, several inhibitors of NLRP3 inflammasome
… Here, we describe some recent pharmacological inhibitors of NLRP3 inflammasome …

… were identified as novel IL-1β processing inhibitors 18 . In this study we investigated one
of … potent specific NLRP3 inhibitor that was observed to be active in vivo in multiple NLRP3-…

… Although this review focuses only on direct inhibition of the NLRP3 inflammasome, there is
significant interest in the inhibition of upstream processes, which again may lessen the risk of …

… to inhibit NLRP3 inflammasome activation and might have unspecific effects. Here we
describe CY-09 as a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself …

… interest that pharmacological inhibitors of BTK were able to inhibit NLRP3 activation, …
inflammasome and that BTK inhibitors could therefore be potentially repurposed to inhibit NLRP3. …

… genetic inactivation of the NLRP3 inflammasome improves behavioral tests and … inhibition
of the NLRP3 inflammasome using dapansutrile (OLT1177), an oral NLRP3-specific inhibitor …

… the NLRP3 inflammasome is discussed with focus on pharmacological inhibition of NLRP3
by small molecule inhibitors. … insights into NLRP3 activation and inhibitor-NLRP3 interactions …

… effect of NLRP3 inflammasome inhibition and the results of early clinical trials that aimed
to limit the effects of the NLRP3 inflammasome in cardiovascular diseases are promising. …